Protective Effects of the Essential Oil of Salvia fruticosa and Its Constituents on Astrocytic Susceptibility to Hydrogen Peroxide-Induced Cell Death

Oxidative stress has been implicated in pathologic processes associated with neurodegenerative diseases. Astrocytes, the most abundant glial cell type in the brain, protect neurons from reactive oxygen species (ROS), and any damage to them will affect neuronal survival. This study compares the abili...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2009-08, Vol.57 (15), p.6636-6641
Main Authors: Elmann, Anat, Mordechay, Sharon, Rindner, Miriam, Larkov, Olga, Elkabetz, Meital, Ravid, Uzi
Format: Article
Language:English
Subjects:
animal models
Animals
Aroma and flavouring agent industries
astrocytes
Astrocytes - cytology
Astrocytes - drug effects
Bioactive Constituents
Biological and medical sciences
brain
cell death
Cell Death - drug effects
Cell Survival - drug effects
Cells, Cultured
central nervous system diseases
cytosol
essential oils
Food industries
Fundamental and applied biological sciences. Psychology
hydrogen peroxide
Hydrogen Peroxide - pharmacology
Oils, Volatile - pharmacology
oxidative stress
phytochemicals
Plant Oils - pharmacology
Protective Agents - pharmacology
protective effect
Rats
Rats, Wistar
reactive oxygen species
Salvia
Salvia - chemistry
Salvia fruticosa
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Summary:Oxidative stress has been implicated in pathologic processes associated with neurodegenerative diseases. Astrocytes, the most abundant glial cell type in the brain, protect neurons from reactive oxygen species (ROS), and any damage to them will affect neuronal survival. This study compares the ability of essential oils prepared from different herbs and spices to protect cultured primary brain astrocytes from H2O2-induced death. The results show that the essential oil of Salvia fruticosa (Sf) among the tested essential oils demonstrated remarkable protective activity. The protective effect of Sf could be attributed to α-humulene and α-pinene. Following incubation, α-humulene and trans-β-caryophyllene could be found in the cytosol of astrocytes. It is proposed that Sf, by attenuating H2O2-induced cell death, might be used as a functional food or may be offered as a means of therapy in the treatment of neurodegenerative diseases.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf901162f