Anti-phase calcium oscillations in astrocytes via inositol (1, 4, 5)-trisphosphate regeneration

Observations in cultured mouse astrocytes suggest anti-phase synchronization of cytosolic calcium concentrations in nearest neighbor cells that are coupled through gap junctions. A mathematical model is used to investigate physiologic conditions under which diffusion of the second messenger inositol...

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Bibliographic Details
Published in:Cell calcium (Edinburgh) 2006-03, Vol.39 (3), p.197-208
Main Authors: Ullah, Ghanim, Jung, Peter, Cornell-Bell, A.H.
Format: Article
Language:English
Subjects:
Animals
Astrocytes - drug effects
Astrocytes - metabolism
Calcium - metabolism
Calcium Signaling - physiology
Computer Simulation
Cytosol - metabolism
Gap Junctions - physiology
Glutamic Acid - pharmacology
Inositol 1,4,5-Trisphosphate - physiology
Models, Biological
Permeability
Rats
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Summary:Observations in cultured mouse astrocytes suggest anti-phase synchronization of cytosolic calcium concentrations in nearest neighbor cells that are coupled through gap junctions. A mathematical model is used to investigate physiologic conditions under which diffusion of the second messenger inositol (1, 4, 5)-trisphosphate (IP 3) through gap junctions can facilitate synchronized anti-phase Ca 2+ oscillations. Our model predicts anti-phase oscillations in both cytosolic calcium and IP 3 concentrations if (a) the gap junction permeability is within a window of values and (b) IP 3 is regenerated in the astrocytes via, e.g. phospholipase C δ. This result sheds new light on the current dispute on the mechanism of intercellular calcium signaling. It provides indirect evidence for a partially regenerative mechanism as the model excludes anti-phase synchrony in the absence of IP 3 regeneration.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2005.10.009