The role of the amygdala and rostral anterior cingulate in encoding expected outcomes during learning

Successful passive avoidance learning is thought to require the use of learned stimulus-reinforcement associations to guide decision making [Baxter, M.G., Murray, E.A., 2002. The amygdala and reward. Nature Reviews. Neuroscience 3, 563–573]. The current experiment investigated the neural correlates...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006-02, Vol.29 (4), p.1161-1172
Main Authors: Kosson, D.S., Budhani, S., Nakic, M., Chen, G., Saad, Z.S., Vythilingam, M., Pine, D.S., Blair, R.J.R.
Format: Article
Language:English
Subjects:
Adult
Amygdala - blood supply
Amygdala - physiology
Animal behavior
Anxiety
Association Learning - physiology
Avoidance Learning - physiology
Brain
Brain - blood supply
Brain - physiology
Brain Mapping
Echo-Planar Imaging
Female
Gyrus Cinguli - blood supply
Gyrus Cinguli - physiology
Humans
Image Enhancement
Image Processing, Computer-Assisted
Male
Motivation
Nerve Net - physiology
Neural Pathways - physiology
Oxygen - blood
Post traumatic stress disorder
Rodents
Serial Learning - physiology
Set (Psychology)
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Summary:Successful passive avoidance learning is thought to require the use of learned stimulus-reinforcement associations to guide decision making [Baxter, M.G., Murray, E.A., 2002. The amygdala and reward. Nature Reviews. Neuroscience 3, 563–573]. The current experiment investigated the neural correlates of successful passive avoidance learning in 19 healthy adults. Behaviorally, subjects showed a distinct pattern of performance: early indiscriminate responding to stimuli (pre-criterion performance), followed by relatively rapid learning before a plateau of successful performance (post-criterion performance). Neural responses to post-criterion correct responses were compared with neural responses to both incorrect responses and pre-criterion correct responses. Post-criterion correct responding was associated with increased activation in regions including rostral anterior cingulate, insula, caudate, hippocampal regions, and the amygdala.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2005.07.060