Childhood cancer incidence and survival rates in the Rhône-Alpes regional paediatric registry 1987-1999

• Published in: Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2006-02, Vol.13 (2), p.121-129
• Main Authors: Berger, C, Trombert-Paviot, B, Mitton, N, Frappaz, D, Galambrun, C, Plantaz, D, Dupuis, S, Bertrand, Y, Philippe, N, Schell, M, Marec-Bérard, P, Bergeron, C, Armari-Alla, C, Pagnier, A, Stephan, J L, Freycon, F
• Format: Article
• Language: fre
• Subjects: Adolescent; Child; Child, Preschool; Female; France - epidemiology; Humans; Incidence; Infant; Infant, Newborn; Male; Neoplasms - epidemiology; Registries; Survival Rate
• ISSN: 0929-693X
• DOI: 10.1016/j.arcped.2005.10.022

Cancer is rare in children, and pediatric malignancies represent only 1% of all cancers. The cure rate is high and increasing, and ongoing data collection is therefore warranted. Here we report the incidence and survival rates of childhood cancers between 1987 and 1999 in the Rhône-Alpes region of France. A total of 1945 cases were recorded during the study period, with an average of 149.6 new cases per year. The approximate incidence rate was 134.1/10(6) per year and the age-standardized incidence rate was 139.2/10(6) per year. The histological distribution and 5-year survival rates were respectively 30.2 and 73% for leukemia, 12.3 and 91.6% for lymphoma, 24.7 and 60.1% for CNS tumors, 9.1 and 71.1% for neuroblastoma, 2.5 and 94.1% for retinoblastoma, 5.8% and 89.9% for renal tumors, 1 and 75% for liver tumors, 6.1 and 60.9% for bone tumors, 4.1 and 58.6% for soft-tissue tumors, 1.1 and 71% for germ cell tumors, and 2.4 and 85.1% for carcinomas. The overall survival rate was 75%. Long-term treatment complications warrant further studies of children who survive into adulthood.