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Recruitment of Antigen-Specific CD8⁺ T Cells in Response to Infection Is Markedly Efficient
The magnitude of antigen-specific CD8⁺ T cell responses is not fixed but correlates with the severity of infection. Although by definition T cell response size is the product of both the capacity to recruit naïve T cells (clonal selection) and their subsequent proliferation (clonal expansion), it re...
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Published in: | Science (American Association for the Advancement of Science) 2009-09, Vol.325 (5945), p.1265-1269 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The magnitude of antigen-specific CD8⁺ T cell responses is not fixed but correlates with the severity of infection. Although by definition T cell response size is the product of both the capacity to recruit naïve T cells (clonal selection) and their subsequent proliferation (clonal expansion), it remains undefined how these two factors regulate antigen-specific T cell responses. We determined the relative contribution of recruitment and expansion by labeling naïve T cells with unique genetic tags and transferring them into mice. Under disparate infection conditions with different pathogens and doses, recruitment of antigen-specific T cells was near constant and close to complete. Thus, naïve T cell recruitment is highly efficient, and the magnitude of antigen-specific CD8⁺ T cell responses is primarily controlled by clonal expansion. |
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ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.1175455 |