Emergence of oseltamivir-resistant influenza A H1N1 virus during the 2007–2008 winter season in Luxembourg: Clinical characteristics and epidemiology

Human cases of oseltamivir-resistant influenza A H1N1 virus emerging in 2007–2008 in Luxembourg were not associated with treatment, prophylaxis or stockpiling of oseltamivir. Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar ep...

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Bibliographic Details
Published in:Antiviral research 2009-10, Vol.84 (1), p.91-94
Main Authors: Mossong, Joël, Opp, Matthias, Gerloff, Nancy, Hau, Patrick, Kremer, Jacques, Lackenby, Angie, Gregory, Vicki, Even, Jos, Huberty-Krau, Pierrette, Muller, Claude P., Schneider, François
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antiviral Agents - therapeutic use
Child
Child, Preschool
Drug Resistance, Viral
Epidemiology
Female
H1N1
Humans
Influenza
Influenza A Virus, H1N1 Subtype - classification
Influenza A Virus, H1N1 Subtype - drug effects
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza A Virus, H1N1 Subtype - physiology
Influenza, Human - drug therapy
Influenza, Human - epidemiology
Influenza, Human - virology
Luxembourg - epidemiology
Male
Molecular Sequence Data
Oseltamivir
Oseltamivir - therapeutic use
Phylogeny
Resistance
Seasons
Young Adult
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Description
Summary:Human cases of oseltamivir-resistant influenza A H1N1 virus emerging in 2007–2008 in Luxembourg were not associated with treatment, prophylaxis or stockpiling of oseltamivir. Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar epidemiology and clinical symptoms.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2009.08.001