Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam ®) assay

The strategic use of the gamma-interferon (IFN-γ) assay (Bovigam ®) can provide a means for the early identification of Mycobacterium bovis infected cattle, thus ensuring their removal from an infected herd. When used in parallel with the tuberculin test, it is capable of identifying infected cattle...

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Bibliographic Details
Published in:Veterinary microbiology 2006-02, Vol.112 (2), p.171-179
Main Authors: Gormley, E., Doyle, M.B., Fitzsimons, T., McGill, K., Collins, J.D.
Format: Article
Language:English
Subjects:
animal pathogenic bacteria
Animals
Biological and medical sciences
bovine tuberculosis
Cattle
culling (animals)
Dexamethasone
diagnostic techniques
disease control
disease control programs
disease diagnosis
disease prevalence
disease transmission
early diagnosis
Fundamental and applied biological sciences. Psychology
Gamma-interferon
Interferon-gamma - biosynthesis
Interferon-gamma - blood
Interferon-gamma - drug effects
interferons
Ireland
literature reviews
Longitudinal Studies
Malnutrition - veterinary
Microbiology
Mycobacterium bovis
Mycobacterium bovis - immunology
Sensitivity and Specificity
SICTT
Time Factors
Tuberculin
Tuberculin Test - standards
Tuberculin Test - veterinary
Tuberculosis, Bovine - diagnosis
Tuberculosis, Bovine - immunology
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Summary:The strategic use of the gamma-interferon (IFN-γ) assay (Bovigam ®) can provide a means for the early identification of Mycobacterium bovis infected cattle, thus ensuring their removal from an infected herd. When used in parallel with the tuberculin test, it is capable of identifying infected cattle, which might otherwise not be detected until later, if at all. The early detection and removal of these animals reduces the risk that they will become a source of infection for other cattle. When targeted in herds of high prevalence the benefits to the herd owner directly concerned can be considerable as the assay provides a means of shortening the period of restriction for such herds. This serves to generate confidence among herd owners and other stakeholders that effective schemes, based on sound scientific principles, can be developed to eradicate tuberculosis from infected cattle populations.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2005.11.029