Process Simulation in the Pharmaceutical Industry: A Review of Some Basic Physical Models

This study reviews process modeling efforts which have been developed to elucidate the fundamental physical process underlying the manufacture and delivery of pharmaceutical dosage forms. Within the pharmaceutical industry, process models have been applied to a diverse array of physical processes at...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2006-03, Vol.95 (3), p.517-529
Main Authors: Kremer, D.M., Hancock, B.C.
Format: Article
Language:English
Subjects:
aerosol
Biological and medical sciences
Chemistry, Pharmaceutical
compaction
computer modeling
Drug Industry
freeze-drying
General pharmacology
lyophilization
Medical sciences
mixing
Models, Theoretical
pharmaceutical engineering
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physical Phenomena
Physics
powder technology
spray drying
tableting
unit operations
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Summary:This study reviews process modeling efforts which have been developed to elucidate the fundamental physical process underlying the manufacture and delivery of pharmaceutical dosage forms. Within the pharmaceutical industry, process models have been applied to a diverse array of physical processes at length and time scales that vary by orders of magnitude. As such, both large-scale continuum and particle-scale discrete approaches will be discussed in this study. Challenges associated with the practical application of process models within the pharmaceutical industry will be discussed, and opportunities for future research will be identified. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.20583