Inhibition of lipid peroxidation, cyclooxygenase enzyme and human tumor cell proliferation by compounds in herbal water

A powdered mixture of dried herbs, "Panamrutham", is sold in India for the preparation of "herbal drinking water". The hot water extract of this herbal mixture gave lipid peroxidation (LPO), cyclo-oxygenase (COX-1 and -2) enzyme and human tumor cell proliferation inhibitory activ...

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Bibliographic Details
Published in:Molecular nutrition & food research 2009-09, Vol.53 (9), p.1177-1186
Main Authors: Liu, Yunbao, Mulabagal, Vanisree, Bowen-Forbes, Camille S, Aviayan, Rejanish, Nair, Muraleedharan G
Format: Article
Language:English
Subjects:
Anticancer
Antiinflammatory
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidant
Antioxidants - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cell Proliferation - drug effects
Cyclooxygenase Inhibitors - pharmacology
Food industries
Fundamental and applied biological sciences. Psychology
Heterodimer
Humans
Lipid Peroxidation - drug effects
Magnetic Resonance Spectroscopy
Plant Extracts - pharmacology
Protosappanin
Spectrometry, Mass, Electrospray Ionization
Water
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Summary:A powdered mixture of dried herbs, "Panamrutham", is sold in India for the preparation of "herbal drinking water". The hot water extract of this herbal mixture gave lipid peroxidation (LPO), cyclo-oxygenase (COX-1 and -2) enzyme and human tumor cell proliferation inhibitory activities between 25 and 250 μg/mL. The bioassay-guided purification of the water extract afforded a novel compound (1), along with phenolics (2, 4, 6, and 7) and sesquiterpenoids (3 and 5). The isolates were evaluated for LPO, COX-1 and -2 enzyme and human tumor cell proliferation inhibitory activities. At 25 μg/mL, compounds 1-7 inhibited LPO by 22-73% and COX-1 and -2 enzymes by 3-14% and 14-74%, respectively. Compounds 5 and 6 at 25 μg/mL showed growth inhibition of colon, gastric, lung, breast and central nervous system human tumor cell lines by 60 and 67, 43 and 60, 24 and 64, 34 and 65, 6 and 27%, respectively. Compounds 2, 4 and 7 displayed weak or moderate growth inhibition of colon, gastric and breast human tumor cell lines. This is the first report on the LPO inhibitory activities of compounds 1 and 3-7 and the COX and tumor cell proliferation inhibitory activities of compounds 1, 3-5 and 7.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.200800545