Evaluation of rat and rabbit sera lipoproteins in experimentally induced hyperlipidemia by analytical ultracentrifugation

Animals of various species are widely used as models with which to study atherosclerosis and the lipoprotein metabolism. The objective of this study was to investigate the lipoprotein profiles in Wistar rats and New Zealand white rabbits with experimentally induced hyperlipidemia by means of ultrace...

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Bibliographic Details
Published in:European biophysics journal 2006-02, Vol.35 (3), p.205-213
Main Authors: Bozóky, Z, Balogh, L, Máthé, D, Fülöp, L, Jánoki, Gy A
Format: Article
Language:English
Subjects:
Age Factors
Animals
Atherosclerosis
Blood
Centrifugation, Density Gradient - methods
Cholesterol
Cholesterol, Dietary - administration & dosage
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cholesterol, VLDL - blood
Disease Models, Animal
Flotation
Hypercholesterolemia - blood
Lipoproteins
Microscopy, Ultraviolet
Polyethylene Glycols - administration & dosage
Rabbits
Radioisotopes - blood
Radionuclide Imaging
Rats
Rats, Wistar
Refractometry
Rodents
Species Specificity
Technetium
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Summary:Animals of various species are widely used as models with which to study atherosclerosis and the lipoprotein metabolism. The objective of this study was to investigate the lipoprotein profiles in Wistar rats and New Zealand white rabbits with experimentally induced hyperlipidemia by means of ultracentrifugation. The Schlieren curves were utilized to compare suckling and adult rat sera to determine whether aging causes alterations in lipoprotein profiles. A striking feature of the data is the high concentration of low-density lipoproteins (LDL), (>5.2 mmol/l cholesterol) in the 2-week old rat serum pool which was greatly decreased in the 3-weeks rat serum pool (
ISSN:0175-7571
1432-1017
DOI:10.1007/s00249-005-0022-x