The pivotal nature of sugars in normal physiology and disease

Glycopathology has become the focus of considerable research in recent years as the role of glycosylation in the development, regulation, and progression of disease has come under increased scrutiny. Cracking the 'sugar-code' in biological systems that relate to both health and disease hol...

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Bibliographic Details
Published in:Wiener medizinische Wochenschrift 2006-01, Vol.156 (1-2), p.19-33
Main Authors: Alavi, Azita, Axford, John S
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - physiopathology
Carbohydrates - physiology
Computer Simulation
Glycosylation
Humans
Immunoglobulin Fc Fragments - genetics
Immunoglobulin G - blood
Immunoglobulin G - genetics
Models, Genetic
Protein Processing, Post-Translational - genetics
Synovial Membrane - immunology
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Summary:Glycopathology has become the focus of considerable research in recent years as the role of glycosylation in the development, regulation, and progression of disease has come under increased scrutiny. Cracking the 'sugar-code' in biological systems that relate to both health and disease holds tremendous promise for deciphering disease mechanisms such as the link between the glycomodification of immunoglobulins and various autoimmune diseases, notably IgG in rheumatoid arthritis (RA), and has exciting implications for the development of novel diagnostic and therapeutic interventions.
ISSN:0043-5341
1563-258X
DOI:10.1007/s10354-005-0247-4