Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)

Objectives: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes percepti...

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Bibliographic Details
Published in:Quality of life research 2006-03, Vol.15 (2), p.299-305
Main Authors: Propert, K. J., Litwin, M. S., Wang, Y., Alexander, R. B., Calhoun, E., Nickel, J. C., O'Leary, M. P., Pontari, M., McNaughton-Collins, M., (CPCRN)</gn>, <gn>The Chronic Prostatitis Collaborative Research Network
Format: Article
Language:English
Subjects:
Adult
Brief Communications
Chronic Disease
Clinical trials
Confidence interval
Confidence intervals
Humans
Male
Medical schools
Men
Middle Aged
National Institutes of Health (U.S.)
Pain
Pain Measurement
Pelvic pain
Prostatitis
Prostatitis - physiopathology
Quality of Life
Research universities
Surveys and Questionnaires
Symptoms
United States
Urology
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Summary:Objectives: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes perceptible to patients. Methods: We studied 174 men with CP/CPPS who participated in a placebo-controlled randomized clinical trial. Changes from baseline to six weeks in the NIH-CPSI total score and pain, urinary, and quality of life subscores were compared to a global response assessment (GRA). Effect sizes and Guyatt statistics were calculated to evaluate responsiveness; 95% confidence intervals were produced using bootstrapping. Results: All scores decreased over time with the largest decrease in subjects who reported on the GRA that they were markedly improved. The NIH-CPSI total, pain, and quality of life scores were highly responsive in the improved groups; the urinary score showed minimal responsiveness. There was no evidence of responsiveness among those subjects who worsened on the trial. ROC curves identified a 6-point decline in the NIH-CPSI total score as the optimal threshold to predict treatment response. Conclusions: The NIH-CPSI total score and pain and quality of life subscores are responsive to change over time.
ISSN:0962-9343
1573-2649
DOI:10.1007/s11136-005-1317-1