Mechanisms of immune-mediated skin diseases : an overview

The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective imm...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2006, Vol.24 (1), p.S1-S6
Main Authors: BEISSERT, S, CAVAZZANA, I, MASCIA, F, MERONI, P, PASTORE, S, TESSARI, G, GIROLOMONI, G
Format: Article
Language:English
Subjects:
Autoantibodies - immunology
Autoimmune Diseases - immunology
Biological and medical sciences
CD40 Antigens - immunology
CD40 Ligand - immunology
Chronic Disease
Dermatitis - immunology
Diseases of the osteoarticular system
Humans
Keratinocytes - immunology
Medical sciences
Skin Diseases - immunology
T-Lymphocytes - immunology
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Summary:The skin is a frequent site of pathological immune responses that can take place in the dermal and/or the epidermal compartments.These immunopathological reactions often occur towards innocuous antigens and may be the result of T cell-dependent and/or autoantibody dependent mechanisms. Defective immune regulation is increasingly recognized as very relevant in many skin and systemic immune-mediated disorders. In some instances (e.g., psoriasis and atopic dermatitis) genetic predisposition can affect also the capacity of keratinocytes to initiate or perpetuate inflammatory responses. A more precise understanding of the molecular and cellular mechanisms underlying each disorder may allow the identification of novel targets for more effective therapeutic strategies.
ISSN:0392-856X
1593-098X