Impact of elective resection on plasma TIMP-1 levels in patients with colon cancer

• Published in: Colorectal disease 2006-03, Vol.8 (3), p.168-172
• Main Authors: Hammer, J. H., Basse, L., Svendsen, M. N., Werther, K., Brünner, N., Christensen, I. J., Nielsen, H. J.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Colon cancer; Colonic Neoplasms - blood; Colonic Neoplasms - surgery; Enzyme-Linked Immunosorbent Assay; fast track recovery; Female; Humans; laparoscopic surgery; Laparoscopy; Linear Models; Male; Middle Aged; open surgery; Prognosis; TIMP-1; Tissue Inhibitor of Metalloproteinase-1 - blood
• ISSN: 1462-8910; 1463-1318
• DOI: 10.1111/j.1463-1318.2005.00831.x

Objective  Pre‐ and post‐operative plasma tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have a prognostic impact on patients with colorectal cancer. However, the surgical trauma may play an essential role in regulation of plasma TIMP‐1 levels, which in turn may influence subsequent TIMP‐1 measurements. Patients and methods  Consecutively, 48 patients with colon cancer (CC) and 12 patients with nonmalignant colonic disease were randomised to undergo elective laparoscopically assisted or open resection followed by fast track recovery. Plasma samples were collected just before and 1, 2 and 6 h after skin incision, and 1, 2, 8 and 30 days after surgery. TIMP‐1 was determined concurrently in all samples by a validated ELISA method. Results  Geometric mean preoperative TIMP‐1 level was 142 ng/ml (range 54–559 ng/ml) among CC patients compared with 106 ng/ml (range 64–167 ng/ml) among patients with nonmalignant diseases (P