Detection of pericardial inflammation with late-enhancement cardiac magnetic resonance imaging: initial results

To examine the value of late-enhancement cardiac magnetic resonance imaging (MRI) for detection of pericardial inflammation. Late-enhancement cardiac MRI was performed in 16 patients with clinical suspicion of pericardial disease. Pericardial effusion, pericardial thickening and pericardial enhancem...

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Bibliographic Details
Published in:European radiology 2006-03, Vol.16 (3), p.569-574
Main Authors: Taylor, Andrew M, Dymarkowski, Steven, Verbeken, Eric K, Bogaert, Jan
Format: Article
Language:English
Subjects:
Adult
Aged
Contrast Media
Coronary artery disease
Disease control
Effusion
Female
Gadolinium DTPA
Heart diseases
Histology
Humans
Inflammation
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical imaging
Microbiology
Middle Aged
Pericarditis
Pericarditis - diagnosis
Pericarditis - microbiology
Pericardium
Sensitivity and Specificity
Thickening
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Summary:To examine the value of late-enhancement cardiac magnetic resonance imaging (MRI) for detection of pericardial inflammation. Late-enhancement cardiac MRI was performed in 16 patients with clinical suspicion of pericardial disease. Pericardial effusion, pericardial thickening and pericardial enhancement were assessed. MRI findings were compared with those of definitive pericardial histology (n=14) or microbiology (n=2). A control group of 12 patients with no clinical evidence of pericardial disease were also imaged with the same MRI protocol. Sensitivity and specificity for late-enhancement MRI detection of pericardial inflammation was of 100%. There was MRI late enhancement of the pericardial layers in all five patients with histological/microbiological evidence of inflammatory pericarditis. MRI demonstrated no pericardial thickening and no MRI late enhancement with or without a pericardial effusion in any of the five patients with histological evidence of a normal pericardium. MRI detected pericardial thickening in the absence of both pericardial effusion and late enhancement in all six patients with histological evidence of chronic fibrosing pericarditis. The 12 control subjects showed no evidence of pericardial MRI late enhancement. These findings demonstrate that MRI late enhancement can be used to visualize pericardial inflammation in patients with clinical suspicion of pericardial disease.
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-005-0025-0