The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat

Objective: Peptide YY3-36 (PYY 3–36 ), glucagon-like peptide-1 (GLP-1), oxyntomodulin and cholecystokinin (CCK) are gastrointestinal-derived hormones that are released postprandially in proportion to the amount of calories ingested. All significantly reduce food intake following peripheral administr...

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Bibliographic Details
Published in:International Journal of Obesity 2006-02, Vol.30 (2), p.288-292
Main Authors: Abbott, C R, Small, C J, Sajedi, A, Smith, K L, Parkinson, J R C, Broadhead, L L, Ghatei, M A, Bloom, S R
Format: Article
Language:English
Subjects:
Acclimatization
alpha-MSH - analogs & derivatives
alpha-MSH - pharmacology
Animal Husbandry
Animals
Biological and medical sciences
Control
Eating - drug effects
Environment
Epidemiology
Exposure
Food
Gastrointestinal hormones
Gastrointestinal Hormones - pharmacology
Glucagon
Glucagon-Like Peptide 1 - pharmacology
Glucagon-Like Peptides - pharmacology
Habituation, Psychophysiologic
Health aspects
Health Promotion and Disease Prevention
Hormones
Hormones. Endocrine system
Ingestion
Internal Medicine
Investigations
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Models, Animal
original-article
Oxyntomodulin
Peptide Fragments
Peptide YY - pharmacology
Peptides
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Public Health
Rats
Rats, Wistar
Rodents
Satiety Response
Sincalide - pharmacology
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Summary:Objective: Peptide YY3-36 (PYY 3–36 ), glucagon-like peptide-1 (GLP-1), oxyntomodulin and cholecystokinin (CCK) are gastrointestinal-derived hormones that are released postprandially in proportion to the amount of calories ingested. All significantly reduce food intake following peripheral administration to rodents. We have investigated the effect of handling, exposure to a novel environment or to environmental enrichment on the anorectic effect of these gut hormones. Results: Results suggest that the transfer of a rat into a novel environment (cage change) inhibits the anorectic response to peripherally administered PYY 3–36 and oxyntomodulin (1 h food intake reduction (% saline control): PYY/home cage 82.3±5.9%, P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0803137