Red algal cellular biomass lowers circulating cholesterol concentrations in Syrian golden hamsters consuming hypercholesterolaemic diets

• Published in: British journal of nutrition 2009-09, Vol.102 (6), p.842-847
• Main Authors: Harding, Scott V., Zhao, Hai Lin, Marinangeli, Christopher P. F., Day, Anthony G., Dillon, Harrison F., Jain, Deepak, Jones, Peter J. H.
• Format: Article
• Language: English
• Subjects: Algae; Animal models; Animals; Biological and medical sciences; Biomass; Biosynthesis; blood glucose; Blood Glucose - metabolism; blood lipids; Body Composition; body fat; cholesteremic effect; Cholesterol; Cholesterol - biosynthesis; Cholesterol - blood; cholesterol fractional synthesis rate; Cholesterol lowering; cholesterol metabolism; Cricetinae; Diet; Diet - adverse effects; diet-related diseases; dietary supplements; Disease Models, Animal; dose response; Eating; energy expenditure; Energy Metabolism; experimental diets; Feeding. Feeding behavior; food intake; Fundamental and applied biological sciences. Psychology; golden hamsters; high density lipoprotein; human nutrition; hypercholesterolemia; Hypercholesterolemia - blood; Hypercholesterolemia - etiology; Hypercholesterolemia - prevention & control; Lipids - blood; Lipoproteins; Mesocricetus; Metabolism and Metabolic Studies; Nutrition; Porphyridium; Porphyridium cruentum; Rodents; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Gain
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1017/S0007114509380046

Preliminary evidence suggests that consumption of Porphyridium cruentum (PC) biomass results in hypocholesterolaemic effects; however, mechanisms responsible have not been elucidated. The aim of the present study was to determine whether PC biomass lowers circulating cholesterol concentrations, dose dependently, in hamsters fed hypercholesterolaemic diets for 28 d and determine whether cholesterol biosynthesis is affected. Biomass added to diets at 2·5, 5 and 10 % resulted in 14, 38 and 53 % reductions (P