Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis

Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immuniz...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2006-02, Vol.16 (2), p.137-143
Main Authors: Tüzün, Erdem, Saini, Shamsher S., Ghosh, Sidharth, Rowin, Julie, Meriggioli, Matthew N., Christadoss, Premkumar
Format: Article
Language:English
Subjects:
Adult
Animals
Anti-C1q antibody
Antibodies, Anti-Idiotypic - blood
Autoimmunity
Circulating immune complexes
Complement C1 - analysis
Complement C1 - immunology
Complement C1q - analysis
Complement C1q - immunology
Complement C3 - analysis
Complement C3 - immunology
Complement Membrane Attack Complex - analysis
Complement Membrane Attack Complex - immunology
Enzyme-Linked Immunosorbent Assay
Experimental autoimmune myasthenia gravis
Female
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Male
Mice
Mice, Inbred C57BL
Middle Aged
Muscle Weakness - physiopathology
Myasthenia gravis
Myasthenia Gravis - blood
Myasthenia Gravis - etiology
Myasthenia Gravis - immunology
Myasthenia Gravis - physiopathology
Myasthenia Gravis, Autoimmune, Experimental - blood
Myasthenia Gravis, Autoimmune, Experimental - etiology
Myasthenia Gravis, Autoimmune, Experimental - immunology
Myasthenia Gravis, Autoimmune, Experimental - physiopathology
Neuromuscular Junction - chemistry
Neuromuscular Junction - pathology
Predictive Value of Tests
Severity of Illness Index
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Summary:Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.
ISSN:0960-8966
1873-2364
DOI:10.1016/j.nmd.2005.11.005