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Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis
Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immuniz...
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| Published in: | Neuromuscular disorders : NMD 2006-02, Vol.16 (2), p.137-143 |
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| container_end_page | 143 |
| container_issue | 2 |
| container_start_page | 137 |
| container_title | Neuromuscular disorders : NMD |
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| creator | Tüzün, Erdem Saini, Shamsher S. Ghosh, Sidharth Rowin, Julie Meriggioli, Matthew N. Christadoss, Premkumar |
| description | Components of the complement cascade and circulating immune complexes play important roles in both experimental autoimmune myasthenia gravis and myasthenia gravis in humans. Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients. |
| doi_str_mv | 10.1016/j.nmd.2005.11.005 |
| format | article |
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Thus far, no serological factor has been identified to predict the clinical severity of either myasthenia gravis. Upon immunization with acetylcholine receptor, levels of complement factors C1q, C3 and CIC increase with time in sera from C57BL/6 (B6) mice. Both these and plasma samples from myasthenia gravis patients also contain anti-C1q antibodies. The serum levels of anti-C1q antibodies but not C1q, C3 and CIC are significantly correlated with the clinical severity in the experimental myasthenia mice. However, this correlation is not observed in myasthenia gravis patients.</description><subject>Adult</subject><subject>Animals</subject><subject>Anti-C1q antibody</subject><subject>Antibodies, Anti-Idiotypic - blood</subject><subject>Autoimmunity</subject><subject>Circulating immune complexes</subject><subject>Complement C1 - analysis</subject><subject>Complement C1 - immunology</subject><subject>Complement C1q - analysis</subject><subject>Complement C1q - immunology</subject><subject>Complement C3 - analysis</subject><subject>Complement C3 - immunology</subject><subject>Complement Membrane Attack Complex - analysis</subject><subject>Complement Membrane Attack Complex - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Experimental autoimmune myasthenia gravis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Middle Aged</subject><subject>Muscle Weakness - physiopathology</subject><subject>Myasthenia gravis</subject><subject>Myasthenia Gravis - blood</subject><subject>Myasthenia Gravis - etiology</subject><subject>Myasthenia Gravis - immunology</subject><subject>Myasthenia Gravis - physiopathology</subject><subject>Myasthenia Gravis, Autoimmune, Experimental - blood</subject><subject>Myasthenia Gravis, Autoimmune, Experimental - etiology</subject><subject>Myasthenia Gravis, Autoimmune, Experimental - immunology</subject><subject>Myasthenia Gravis, Autoimmune, Experimental - physiopathology</subject><subject>Neuromuscular Junction - chemistry</subject><subject>Neuromuscular Junction - pathology</subject><subject>Predictive Value of Tests</subject><subject>Severity of Illness Index</subject><issn>0960-8966</issn><issn>1873-2364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7rr6A7xITt5ak6ZNWjzJ4hcs6EHPIU2mmqUfa5IW99-bdRe8eXpn4JkX5kHokpKUEspv1mnfmTQjpEgpTWMcoTktBUsyxvNjNCcVJ0lZcT5DZ96vCaGF4OIUzSjPM5GVbI7kqwNjdbAT4Em1I-ChwR7c2GHVB5ss6dfvUA9mi1uYoPXY9hi-N-BsB31QLVZjGGzXjT3gbqt8-ITeKvzh1GT9OTppVOvh4pAL9P5w_7Z8SlYvj8_Lu1WiWUFDoirQXAsBTW2quNSVMGBA61rzDAAaVueKQ0VJqYAbVuoGTEMqVpQ1yyBjC3S979244WsEH2RnvYa2VT0Mo5dc8FxUgkWQ7kHtBu8dNHITH1FuKymRO6tyLaNVubMqKZUx4s3VoXysOzB_FweNEbjdA1EPTBac9NpCr6NaBzpIM9h_6n8A2tOLlg</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Tüzün, Erdem</creator><creator>Saini, Shamsher S.</creator><creator>Ghosh, Sidharth</creator><creator>Rowin, Julie</creator><creator>Meriggioli, Matthew N.</creator><creator>Christadoss, Premkumar</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis</title><author>Tüzün, Erdem ; 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| subjects | Adult Animals Anti-C1q antibody Antibodies, Anti-Idiotypic - blood Autoimmunity Circulating immune complexes Complement C1 - analysis Complement C1 - immunology Complement C1q - analysis Complement C1q - immunology Complement C3 - analysis Complement C3 - immunology Complement Membrane Attack Complex - analysis Complement Membrane Attack Complex - immunology Enzyme-Linked Immunosorbent Assay Experimental autoimmune myasthenia gravis Female Humans Immunoglobulin G - blood Immunoglobulin G - immunology Male Mice Mice, Inbred C57BL Middle Aged Muscle Weakness - physiopathology Myasthenia gravis Myasthenia Gravis - blood Myasthenia Gravis - etiology Myasthenia Gravis - immunology Myasthenia Gravis - physiopathology Myasthenia Gravis, Autoimmune, Experimental - blood Myasthenia Gravis, Autoimmune, Experimental - etiology Myasthenia Gravis, Autoimmune, Experimental - immunology Myasthenia Gravis, Autoimmune, Experimental - physiopathology Neuromuscular Junction - chemistry Neuromuscular Junction - pathology Predictive Value of Tests Severity of Illness Index |
| title | Predictive value of serum anti-C1q antibody levels in experimental autoimmune myasthenia gravis |
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