Intrinsic in vitro susceptibility of primary clinical isolates of Aspergillus fumigatus, Aspergillus terreus, Aspergillus nidulans, Candida albicans and Candida lusitaniae against amphotericin B

Summary A total of 60 clinical fungal isolates from patients without prior amphotericin B treatment and three control strains were evaluated for their intrinsic susceptibility to amphotericin B (AmB) using microdilution, Etest and disc diffusion assays, on three media each, Roswell Park Memorial Ins...

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Bibliographic Details
Published in:Mycoses 2006-03, Vol.49 (2), p.96-103
Main Authors: Singh, Jagpal, Rimek, Dagmar, Kappe, Reinhard
Format: Article
Language:English
Subjects:
amphotericin B
Amphotericin B - pharmacology
Antifungal Agents - pharmacology
Aspergillus
Aspergillus - drug effects
Aspergillus - isolation & purification
Aspergillus fumigatus
Aspergillus fumigatus - drug effects
Aspergillus fumigatus - isolation & purification
Aspergillus nidulans
Aspergillus nidulans - drug effects
Aspergillus nidulans - isolation & purification
Aspergillus terreus
Candida
Candida - drug effects
Candida - isolation & purification
Candida albicans
Candida albicans - drug effects
Candida albicans - isolation & purification
Candida lusitaniae
Culture Media
Humans
Microbial Sensitivity Tests - methods
Mycoses - microbiology
susceptibility testing
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Summary:Summary A total of 60 clinical fungal isolates from patients without prior amphotericin B treatment and three control strains were evaluated for their intrinsic susceptibility to amphotericin B (AmB) using microdilution, Etest and disc diffusion assays, on three media each, Roswell Park Memorial Institute (RPMI) 1640, Antibiotic Medium 3 (AM3) and High Resolution Medium. The fungal strains included isolates of Aspergillus fumigatus (n = 10), Aspergillus terreus (n = 12), Aspergillus nidulans (n = 9), Candida albicans (n = 6) and Candida lusitaniae (n = 23). The A. terreus strains were significantly less susceptible to AmB than the A. fumigatus strains in all nine experimental settings (P‐values ranging from 0.009 to
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2006.01197.x