Obesity and cancer

Obesity which is now well recognized as a public health problem increases the risk of developing cancers. Some systematic review and meta-analyses assessed the strength of associations between body mass index and common cancers such as breast, endometrial, colon and adenocarcinoma of oesophagus. The...

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Bibliographic Details
Published in:La revue de medecine interne 2009-09, Vol.30 (9), p.776-782
Main Authors: Schlienger, J-L, Luca, F, Vinzio, S, Pradignac, A
Format: Article
Language:fre
Subjects:
Adenocarcinoma - epidemiology
Adolescent
Adult
Aged
Animals
Biomarkers
Body Mass Index
Breast Neoplasms - epidemiology
Case-Control Studies
Cohort Studies
Colonic Neoplasms - epidemiology
Disease Models, Animal
Energy Intake
Esophageal Neoplasms - epidemiology
Exercise
Female
Humans
Hyperinsulinism - complications
Hyperinsulinism - physiopathology
Insulin-Like Growth Factor I - physiology
Life Style
Male
Meta-Analysis as Topic
Middle Aged
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - physiopathology
Obesity - complications
Obesity - physiopathology
Obesity - prevention & control
Prognosis
Prospective Studies
Prostatic Neoplasms - epidemiology
Risk
Risk Factors
Sex Factors
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Description
Summary:Obesity which is now well recognized as a public health problem increases the risk of developing cancers. Some systematic review and meta-analyses assessed the strength of associations between body mass index and common cancers such as breast, endometrial, colon and adenocarcinoma of oesophagus. The causal mechanisms remain unexplained. However, epidemiological data and animal models have provided some evidence that hormonal alteration linked to obesity, such as hyperinsulinism, high insulin-like growth factor (IGF-1) levels or biodisponibility, low adiponectin serum level and high oestradiol serum level resulting from an enhanced aromatase activity may have mitogenic and antiapoptotic effects. The inflammation associated with visceral adiposity is another factor which promotes cancer. To date, there are no convincing data that weight loss could improve the prognosis of treated neoplasia. However, a regular physical activity and a limited caloric intake are probably safe in healthy subject to prevent cancer and also in cancer survivors.
ISSN:0248-8663
DOI:10.1016/j.revmed.2009.04.007