Residual minimal disease activity in rheumatoid arthritis: a simple definition through an in-depth statistical analysis of the major outcome

Objective. To obtain the simplest definition of minimal disease activity (MDA) and to compare it with published proposed definitions of MDA in patients with RA. Methods. Two hundred and fourteen patients with long-standing RA (LSRA) were evaluated for clinical and laboratory parameters. Factor analy...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2009-10, Vol.48 (10), p.1242-1246
Main Authors: Pietrapertosa, Donatello, Salaffi, Fausto, Peluso, Giusy, Bosello, Silvia L., Fedele, Anna L., Cuoghi, Ilaria, Michelutti, Alessandro, Gremese, Elisa, Ferraccioli, Gianfranco F.
Format: Article
Language:English
Subjects:
28-Joint disease activity score
Adult
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Blood Sedimentation
Clinical Disease Activity Index
Clinical trials
Disease activity score
Diseases of the osteoarticular system
Epidemiologic Methods
Female
Humans
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Residual minimal disease activity
Rheumatoid arthritis
Simplified Disease Activity Index
Treatment Outcome
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Summary:Objective. To obtain the simplest definition of minimal disease activity (MDA) and to compare it with published proposed definitions of MDA in patients with RA. Methods. Two hundred and fourteen patients with long-standing RA (LSRA) were evaluated for clinical and laboratory parameters. Factor analysis was performed to remove redundant variables included in the core set measure for MDA definition stated by the OMERACT. Receiver operating characteristic (ROC) curves analysis allowed to obtain optimal cut-off predictors of a 28-joint disease activity score (DAS28) ⩽2.85. These were tested in 112 LSRA and 95 early-onset RA (ERA) patients. Results. Factor and ROC curve analysis showed that the best predictors of a DAS28 ⩽ 2.85 in LSRA cohort were: (i) ESR
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kep217