Fibroadenoma and intraduct papilloma—a common pathogenesis?

This report describes two cases, each showing fibroepithelial proliferation, admixed with intraduct papillomas. Case 1 was from a 13-year-old female who presented with a breast mass, while case 2 was from a 60-year-old female who also had a breast lump. Case 1 showed proliferative breast disease wit...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2009-09, Vol.455 (3), p.271-275
Main Authors: Cummings, Margaret C., da Silva, Leonard, Papadimos, David J., Lakhani, Sunil R.
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Breast Neoplasms - etiology
Breast Neoplasms - pathology
Case Report
Female
Fibroadenoma - etiology
Fibroadenoma - pathology
Gynecology. Andrology. Obstetrics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Ki-67 Antigen - analysis
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Papilloma, Intraductal - etiology
Papilloma, Intraductal - pathology
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Tumors
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Summary:This report describes two cases, each showing fibroepithelial proliferation, admixed with intraduct papillomas. Case 1 was from a 13-year-old female who presented with a breast mass, while case 2 was from a 60-year-old female who also had a breast lump. Case 1 showed proliferative breast disease with multiple small papillomas, some with leaf-like contours. Broad-based parenchymal proliferations protruding into ducts were also seen, and there were overlap features between the two ends of this spectrum. Case 2, similarly, demonstrated a mixed intraductal proliferation, with papillomas on narrow stalks together with low-grade phyllode areas extending into ducts from a wider base. That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-009-0817-8