Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaraná, on mouse hepatocarcinogenesis

Guaraná ( Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gros...

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Bibliographic Details
Published in:Cancer letters 2006-02, Vol.233 (1), p.158-164
Main Authors: Fukumasu, Heidge, Silva, Tereza Cristina da, Avanzo, José Luis, Lima, Cyntia Esteves de, Mackowiak, Ivone Isabel, Atroch, André, Spinosa, Helenice de Souza, Moreno, Fernando Salvador, Dagli, Maria Lucia Zaidan
Format: Article
Language:English
Subjects:
Animals
Caffeine - pharmacology
Carcinogenesis
Carcinogens
Chemoprevention
Female
Food
Guaraná
Liver
Liver Neoplasms, Experimental - pathology
Liver Neoplasms, Experimental - prevention & control
Mice
Mice, Inbred BALB C
Paullinia
Paullinia cupana
PCNA
Phytotherapy
Plant Extracts - therapeutic use
Precancerous Conditions - prevention & control
Proliferating Cell Nuclear Antigen - analysis
Proteins
Studies
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Summary:Guaraná ( Paullinia cupana) is originally from Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guaraná presented inhibitory effects on DEN hepatocarcinogenesis in mice.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.03.007