Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells

Midkine is a heparin-binding growth factor and is expressed by a number of tumor cells, contributing to their growth both in vitro and in vivo. Spontaneous lung metastasis of Lewis lung carcinoma cells, which did not significantly express MK, was significantly less extensive in mice deficient in the...

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Bibliographic Details
Published in:Cancer letters 2006-02, Vol.233 (1), p.16-20
Main Authors: Salama, Ragaa H.M., Muramatsu, Hisako, Zou, Peng, Okayama, Minoru, Muramatsu, Takashi
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Lewis Lung - pathology
Chemokines
Colorectal cancer
Cytokines - antagonists & inhibitors
Cytokines - genetics
Cytokines - physiology
Experiments
Growth factor
Immune system
Lewis lung carcinoma cells
Low density lipoprotein receptors
Lung Neoplasms - secondary
Mice
Mice, Inbred C57BL
Midkine
Migration
Molecular weight
Oligonucleotides, Antisense - therapeutic use
Proteins
Rodents
Tumor metastasis
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Summary:Midkine is a heparin-binding growth factor and is expressed by a number of tumor cells, contributing to their growth both in vitro and in vivo. Spontaneous lung metastasis of Lewis lung carcinoma cells, which did not significantly express MK, was significantly less extensive in mice deficient in the midkine gene than in wild-type mice, when the tumor was subcutaneously grown above the thigh. Midkine strongly enhanced migration of Lewis lung carcinoma cells in vitro. Therefore, midkine is also a host factor enhancing tumor metastasis. Anti-midkine therapy for malignancy may act on midkine produced by both the tumor and host.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2005.02.047