Functional imaging using the retinal function imager: Direct imaging of blood velocity, achieving fluorescein angiography-like images without any contrast agent, qualitative oximetry, and functional metabolic signals

The Retinal Function Imager (RFI; Optical Imaging, Rehovot, Israel) is a unique, noninvasive multiparameter functional imaging instrument that directly measures hemodynamic parameters such as retinal blood-flow velocity, oximetric state, and metabolic responses to photic activation. In addition, it...

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Bibliographic Details
Published in:Japanese journal of ophthalmology 2009-07, Vol.53 (4), p.345-351
Main Authors: Izhaky, David, Nelson, Darin A., Burgansky-Eliash, Zvia, Grinvald, Amiram
Format: Article
Language:English
Subjects:
Animals
Blood Flow Velocity - physiology
Contrast Media - administration & dosage
Diagnostic Imaging - instrumentation
Diagnostic Imaging - methods
Fluorescein Angiography
Humans
Medicine
Medicine & Public Health
Ophthalmology
Oximetry
Oxygen - blood
Regional Blood Flow - physiology
Retina - physiology
Retinal Vessels - physiology
Review
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Summary:The Retinal Function Imager (RFI; Optical Imaging, Rehovot, Israel) is a unique, noninvasive multiparameter functional imaging instrument that directly measures hemodynamic parameters such as retinal blood-flow velocity, oximetric state, and metabolic responses to photic activation. In addition, it allows capillary perfusion mapping without any contrast agent. These parameters of retinal function are degraded by retinal abnormalities. This review delineates the development of these parameters and demonstrates their clinical applicability for noninvasive detection of retinal function in several modalities. The results suggest multiple clinical applications for early diagnosis of retinal diseases and possible critical guidance of their treatment.
ISSN:0021-5155
1613-2246
DOI:10.1007/s10384-009-0689-0