The role of emerging techniques in the investigation of prolidase deficiency: From diagnosis to the development of a possible therapeutical approach

The aim of the present article is to review the efforts performed in the past two decades by numerous research groups for the development of methods that allow a correct diagnosis of prolidase deficiency (PD), a rare autosomal recessive disorder and for the rationalization of a possible therapeutic...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2006-02, Vol.832 (1), p.1-8
Main Authors: Viglio, Simona, Annovazzi, Laura, Conti, Bice, Genta, Ida, Perugini, Paola, Zanone, Chiara, Casado, Begoña, Cetta, Giuseppe, Iadarola, Paolo
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Capillary electrophoresis
Diagnosis
Dipeptidases - deficiency
Electrophoresis, Capillary
Fundamental and applied biological sciences. Psychology
General pharmacology
Genes, Recessive
Genetic Diseases, Inborn - diagnosis
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - therapy
Humans
Imidodipeptides
Liposomes
Medical sciences
Pharmacology. Drug treatments
Prolidase deficiency
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Urine
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Summary:The aim of the present article is to review the efforts performed in the past two decades by numerous research groups for the development of methods that allow a correct diagnosis of prolidase deficiency (PD), a rare autosomal recessive disorder and for the rationalization of a possible therapeutic intervention on these patients. In particular, the interest of the reader is focused on the application of capillary electrophoresis (i) for the detection of biological markers that reflect the pathological feature of the disease and (ii) for the determination of the efficiency of a carrier system in delivering prolidase inside cells in a possible therapy based on enzyme replacement.
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2005.12.049