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Detection of Immunoglobulin M Antibody to Hepatitis A Virus in Patients without Acute Hepatitis A: The Usefulness of Specific Immunoglobulin G Avidity

Immune cells may become activated during viral infections or immune diseases; thus, IgM antibodies directed against specific viral antigens can be detected because of nonspecific polyclonal activation of memory cells resulting from a previous infection with an unrelated agent [4-6]. However, many vi...

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Bibliographic Details
Published in:Clinical infectious diseases 2006-03, Vol.42 (6), p.887-888
Main Authors: Roque-Afonso, Anne Marie, Mackiewicz, Vincent, Dussaix, Elisabeth
Format: Article
Language:English
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Summary:Immune cells may become activated during viral infections or immune diseases; thus, IgM antibodies directed against specific viral antigens can be detected because of nonspecific polyclonal activation of memory cells resulting from a previous infection with an unrelated agent [4-6]. However, many viral infections or immune diseases may cause hepatitis, and in some of these cases, antiHAV IgM may be detected because of polyclonal activation of the immune system.
ISSN:1058-4838
1537-6591
DOI:10.1086/500260