Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead?

Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2009-09, Vol.69 (18), p.7140-7150
Main Authors: ORDONEZ, José Luis, OSUNA, Daniel, HERRERO, David, DE ALAVA, Enrique, MADOZ-GURPIDE, Juan
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Diseases of the osteoarticular system
Humans
Medical sciences
Mice
Oncogene Proteins, Fusion - genetics
Oncogene Proteins, Fusion - metabolism
Pharmacology. Drug treatments
Proto-Oncogene Protein c-fli-1 - genetics
Proto-Oncogene Protein c-fli-1 - metabolism
RNA-Binding Protein EWS
Sarcoma, Ewing - genetics
Sarcoma, Ewing - metabolism
Sarcoma, Ewing - pathology
Sarcoma, Ewing - therapy
Tumors
Tumors of striated muscle and skeleton
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Summary:Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors. Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the development of genetically engineered mice will hopefully lead to biology-based therapeutic strategies for these tumors.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-08-4041