Transmembrane protein structures without X-rays

Transmembrane (TM) proteins constitute 15–30% of the genome, but 50% of the membrane protein families in eukaryotes lack bacterial homologs. Therefore, it is conceivable that many more years will elapse before high-resolution structures of eukaryotic TM proteins emerge. Until then, integrated approa...

Full description

Saved in:
Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2006-02, Vol.31 (2), p.106-113
Main Authors: Fleishman, Sarel J., Unger, Vinzenz M., Ben-Tal, Nir
Format: Article
Language:English
Subjects:
Bacterial Proteins - chemistry
Cryoelectron Microscopy - methods
Databases, Protein
Membrane Proteins - chemistry
Membrane Proteins - genetics
Models, Molecular
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transmembrane (TM) proteins constitute 15–30% of the genome, but 50% of the membrane protein families in eukaryotes lack bacterial homologs. Therefore, it is conceivable that many more years will elapse before high-resolution structures of eukaryotic TM proteins emerge. Until then, integrated approaches that combine biochemical and computational analyses with low-resolution structures are likely to have increasingly important roles in providing frameworks for the mechanistic understanding of membrane-protein structure and function.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2005.12.005