Serum lipoproteins: Trojan horses of the immune response?

T cells recognizing lipid antigens presented by CD1 molecules have an important role in the immune response. Several lipid antigens for CD1-restricted T cells have been identified, as have some rules of CD1 loading and CD1-restricted presentation. Little is known, however, about the delivery of lipi...

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Bibliographic Details
Published in:Trends in Immunology 2006-02, Vol.27 (2), p.57-59
Main Authors: Schümann, Jens, De Libero, Gennaro
Format: Article
Language:English
Subjects:
Animals
Antigen-Presenting Cells - immunology
Antigens - immunology
Apolipoproteins
Atherosclerosis
Humans
Immunotherapy
Lipids
Lipids - immunology
Lipoproteins
Lipoproteins - blood
Lipoproteins - immunology
Lymphocytes
Proteins
Tumors
Vaccination
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Summary:T cells recognizing lipid antigens presented by CD1 molecules have an important role in the immune response. Several lipid antigens for CD1-restricted T cells have been identified, as have some rules of CD1 loading and CD1-restricted presentation. Little is known, however, about the delivery of lipid antigens from either extracellular compartments or CD1-negative cells to CD1-expressing antigen-presenting cells (APCs). A recent study provides evidence for a role for apolipoprotein E in binding lipid antigens and delivering them to APCs.
ISSN:1471-4906
1471-4981
1365-2567
DOI:10.1016/j.it.2005.12.005