A Chemo-Enzymatic Route to Enantiomerically Pure Cyclic Tertiary Amines

Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2006-02, Vol.128 (7), p.2224-2225
Main Authors: Dunsmore, Colin J, Carr, Reuben, Fleming, Toni, Turner, Nicholas J
Format: Article
Language:English
Subjects:
Amination
Amines - chemical synthesis
Aspergillus niger - enzymology
Biological and medical sciences
Chemistry
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Mechanisms. Catalysis. Electron transfer. Models
Molecular biophysics
Monoamine Oxidase - chemistry
Monoamine Oxidase - metabolism
Organic chemistry
Physical chemistry in biology
Stereoisomerism
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Description
Summary:Deracemization of racemic chiral tertiary amines has been achieved by combination of an enantioselective amine oxidase, obtained through directed evolution, and ammonia borane in a one-pot process.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja058536d