Measuring body composition in chronic heart failure: A comparison of methods

Abstract Aims: Fat-free mass (FFM) is increasingly recognized as a systemic marker of disease severity in chronic organ failure and is an important target for physiologic and pharmacologic interventions to improve functional status. The aim of this study was therefore to evaluate two clinical method...

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Published in:European journal of heart failure 2006-03, Vol.8 (2), p.208-214
Main Authors: Uszko-Lencer, Nicole H.M.K., Bothmer, Francien, van Pol, Petra E.J., Schols, Annemie M.W.J.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - methods
Aged
bioelectrical impedance analysis
Body Composition
Body Weight
Case-Control Studies
Chronic Disease
chronic heart failure
Deuterium
Electric Impedance
Exercise Test
Heart Failure - etiology
Heart Failure - physiopathology
Humans
Indicator Dilution Techniques
Male
Middle Aged
Regression Analysis
Stroke Volume - physiology
Ventricular Dysfunction, Left - complications
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Summary:Abstract Aims: Fat-free mass (FFM) is increasingly recognized as a systemic marker of disease severity in chronic organ failure and is an important target for physiologic and pharmacologic interventions to improve functional status. The aim of this study was therefore to evaluate two clinical methods to assess FFM in patients with chronic heart failure (CHF) using deuterium dilution (DEU) as reference and bromide dilution to assess the ratio between intracellular (ICW) and extracellular water (ECW) as potential confounder. Methods: Body composition was measured with dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA) and DEU in 22 stable patients from our heart failure outpatient clinic and 24 healthy age matched controls. Results: FFM values measured by DXA and DEU in patients (r=0.92, SEE: 3.1 kg) and controls (r=0.99, SEE: 1.3 kg) were strongly related. In both patients and controls, the inter method difference increased with higher values of FFM (DXA overestimating DEU). The ICW/ECW ratio was within the normal range and comparable between the groups. In patients, a highly significant correlation coefficient was found (r=0.93, SEE 2.1 p=0.01) between total body water (DEU) and height squared/resistance (Ht2/R). On multiple regression next to Ht2/R, body weight was an independent predictor of FFMDEU (r=0.95, SEE 2.5 kg, p
ISSN:1388-9842
1879-0844
DOI:10.1016/j.ejheart.2005.07.007