L1 (CD171) is highly expressed in gastrointestinal stromal tumors

The treatment strategy for mesenchymal tumors of the gastrointestinal tract is based upon typing of the tumor. Especially differential diagnosis of gastrointestinal stromal tumors (GISTs) to leiomyomas is crucial for determining radicality of surgery. L1 cell adhesion molecule (CD171) plays an essen...

Full description

Saved in:
Bibliographic Details
Published in:Modern pathology 2006-03, Vol.19 (3), p.399-406
Main Authors: Kaifi, Jussuf T, Strelow, Andrea, Schurr, Paulus G, Reichelt, Uta, Yekebas, Emre F, Wachowiak, Robin, Quaas, Alexander, Strate, Tim, Schaefer, Hansjoerg, Sauter, Guido, Schachner, Melitta, Izbicki, Jakob R
Format: Article
Language:English
Subjects:
Adult
Cell adhesion & migration
Cloning
Connective tissue diseases
Diagnosis, Differential
Fibroids
Fibromatosis, Aggressive - metabolism
Fibromatosis, Aggressive - pathology
gastrointestinal stromal tumors
Gastrointestinal Stromal Tumors - metabolism
Gastrointestinal Stromal Tumors - pathology
Humans
Immunohistochemistry
Kinases
L1 cell adhesion molecule
Laboratory Medicine
Leiomyoma - metabolism
Leiomyoma - pathology
Liver
Medical prognosis
Medicine
Medicine & Public Health
Melanoma
Metastasis
Middle Aged
Nerve Sheath Neoplasms - metabolism
Nerve Sheath Neoplasms - pathology
Neural Cell Adhesion Molecule L1 - biosynthesis
Neurosciences
original-article
Pathology
Smooth muscle
Survival Analysis
Thoracic surgery
tumor markers
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The treatment strategy for mesenchymal tumors of the gastrointestinal tract is based upon typing of the tumor. Especially differential diagnosis of gastrointestinal stromal tumors (GISTs) to leiomyomas is crucial for determining radicality of surgery. L1 cell adhesion molecule (CD171) plays an essential role in tumor progression. The aim of this study was to determine expression of L1 in GISTs, smooth muscle tumors, desmoid-type fibromatosis and peripheral nerve sheath tumors (PNSTs). We retrospectively analyzed a total of 129 surgically resected primary tumors or metastases of 72 GISTs, 29 smooth muscle tumors, seven PNSTs and 21 desmoid-type fibromatosis by immunohistochemistry for c-kit, CD34, smooth muscle actin, desmin, vimentin, S-100 and L1 expression. L1 expression was detected in 53 (74%) of 72 GISTs but in none of 29 smooth muscle tumors or 21 desmoid-type fibromatosis (P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.3800547