Dependence of amygdala activation on echo time: Results from olfactory fMRI experiments

Echo time dependence of the BOLD sensitivity is an important topic in fMRI whenever brain regions are considered where the EPI data quality suffers from susceptibility gradients. Here, an fMRI study is presented showing that a reduced echo time EPI sequence significantly enhances the statistical inf...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006-03, Vol.30 (1), p.151-159
Main Authors: Stöcker, Tony, Kellermann, Thilo, Schneider, Frank, Habel, Ute, Amunts, Katrin, Pieperhoff, Peter, Zilles, Karl, Shah, N. Jon
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Adult
Amygdala
Amygdala - physiology
BOLD sensitivity
Brain - physiology
Brain Mapping
Cerebral Cortex - physiology
Dependence
Echo time
Echo-Planar Imaging
Emotions - physiology
Female
Humans
Image Processing, Computer-Assisted
Magnetic fields
Magnetic Resonance Imaging
Male
Mathematical Computing
Memory, Short-Term - physiology
Models, Statistical
Olfaction
Oxygen - blood
Reference Values
Sensitivity and Specificity
Smell - physiology
Studies
Susceptibility
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Echo time dependence of the BOLD sensitivity is an important topic in fMRI whenever brain regions are considered where the EPI data quality suffers from susceptibility gradients. Here, an fMRI study is presented showing that a reduced echo time EPI sequence significantly enhances the statistical inference in subcortical (limbic) brain regions, with special focus on the amygdala. As a consequence, to facilitate whole-brain fMRI with optimal echo times, a sequence with slice-dependent echo time is demonstrated with a focus on structures suffering from susceptibility changes. The applicability of this method is shown in a second fMRI study aimed at both, cortical, and limbic brain regions. The results are in good agreement with theoretical descriptions of the BOLD sensitivity under the influence of susceptibility gradients.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2005.09.050