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Polyamine effects on cell function: Possible central role of plasma membrane PI(4,5)P2

The polyamines spermidine, spermine, and putrescine are intimately involved in and required for cell growth and proliferation. There are also multiple effects of polyamines on other cellular processes that seem not to be a result of changes in protein expression. It is a daunting task to classify an...

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Published in:	Journal of cellular physiology 2009-12, Vol.221 (3), p.544-551
Main Author:	Coburn, Ronald F.
Format:	Article
Language:	English
Subjects:	Animals Cell Membrane - drug effects Cell Membrane - metabolism Cell Movement - physiology Cell Physiological Phenomena - drug effects Cell Physiological Phenomena - physiology Humans Ion Channel Gating - drug effects Ion Channel Gating - physiology Models, Biological Phosphatidylinositol 4,5-Diphosphate - physiology Polyamines - metabolism Polyamines - pharmacology
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container_title	Journal of cellular physiology
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creator	Coburn, Ronald F.
description	The polyamines spermidine, spermine, and putrescine are intimately involved in and required for cell growth and proliferation. There are also multiple effects of polyamines on other cellular processes that seem not to be a result of changes in protein expression. It is a daunting task to classify and understand cellular effects of endogenous polyamines. There has been no central hypothesis how these effects can occur or how spermine and spermidine could be targeted to various signal transduction cascades. However, now there is evidence that multiple effects of endogenous polyamines on different cellular processes may involve plasma membrane PI(4,5)P2 and recent evidence of how polyamines could be targeted to specific cellular functions. J. Cell. Physiol. 221: 544–551, 2009. © 2009 Wiley‐Liss, Inc.
doi_str_mv	10.1002/jcp.21899
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subjects	Animals Cell Membrane - drug effects Cell Membrane - metabolism Cell Movement - physiology Cell Physiological Phenomena - drug effects Cell Physiological Phenomena - physiology Humans Ion Channel Gating - drug effects Ion Channel Gating - physiology Models, Biological Phosphatidylinositol 4,5-Diphosphate - physiology Polyamines - metabolism Polyamines - pharmacology
title	Polyamine effects on cell function: Possible central role of plasma membrane PI(4,5)P2
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