The second trimester Doppler ultrasound examination is the best predictor of late pregnancy outcome in systemic lupus erythematosus and/or the antiphospholipid syndrome

Objective. To examine the predictive value of clinical examination, laboratory tests and Doppler ultrasound examination in systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) pregnancies. Methods. A prospective study of 116 pregnancies followed in a single tertiary referral cen...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2006-03, Vol.45 (3), p.332-338
Main Authors: Le Thi Huong, D., Wechsler, B., Vauthier-Brouzes, D., Duhaut, P., Costedoat, N., Andreu, M. R., Lefebvre, G., Piette, J.-C.
Format: Article
Language:English
Subjects:
Antiphospholipid syndrome
Antiphospholipid Syndrome - diagnostic imaging
Biological and medical sciences
Cardiovascular system
Diseases of the osteoarticular system
Doppler ultrasound
Female
Fetal Death - etiology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lupus Erythematosus, Systemic - diagnostic imaging
Medical sciences
Pregnancy
Pregnancy Complications - diagnostic imaging
Pregnancy Outcome
Pregnancy Trimester, Second
Prognosis
Prospective Studies
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Systemic lupus erythematosus
Thrombophlebitis - complications
Ultrasonic investigative techniques
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries - diagnostic imaging
Umbilical Arteries - physiopathology
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Summary:Objective. To examine the predictive value of clinical examination, laboratory tests and Doppler ultrasound examination in systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) pregnancies. Methods. A prospective study of 116 pregnancies followed in a single tertiary referral centre. Outcomes analysed were fetal/neonatal death and adverse pregnancy outcome. Univariate analysis was performed for: (i) medical and obstetric history; (ii) medical and obstetric clinical examination; (iii) biological data; (iv) Doppler ultrasound examination. Variables significantly associated with the outcomes in the univariate analysis were entered into a logistic regression model. Results. Sixteen out of 116 pregnancies ended in 12 fetal deaths and 4 embryonic losses. Hence, data for 100 pregnancies were analysed. Seven fetal deaths and one neonatal death occurred, associated with abnormal end-diastolic umbilical artery Doppler flow at the second trimester (P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kei159