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Positron-emission tomography as a prognostic tool for early-stage lung cancer
Positron-emission tomography (PET) shows tissue metabolic activity in the form of the standard uptake value (SUV). This study examines the prognostic value of the SUV for early-stage lung cancer. A retrospective review of 187 patients undergoing PET for potential lung cancer. Data collected included...
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| Published in: | The American journal of surgery 2006-03, Vol.191 (3), p.433-436 |
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| container_title | The American journal of surgery |
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| creator | Kieninger, Alicia N. Welsh, Robert Bendick, Phillip J. Zelenock, Gerald Chmielewski, Gary W. |
| description | Positron-emission tomography (PET) shows tissue metabolic activity in the form of the standard uptake value (SUV). This study examines the prognostic value of the SUV for early-stage lung cancer.
A retrospective review of 187 patients undergoing PET for potential lung cancer. Data collected included patient demographics, tumor pathology, and survival information. Data were correlated with PET results to determine if a prognostic relationship exists.
The sensitivity and specificity of PET for detecting malignant lesions were 98% and 24%. Malignant lesions had a higher SUV than benign lesions (5.9 ± 6.2 versus 2.2 ± 1.8,
P < .0001). The average SUV of well-differentiated tumors was 2.6 ± 3.1 versus 5.9 ± 5.5 for other tumors (
P = .010). There was a strong correlation between tumor stage and SUV (analysis of variance,
P < .0001). There was no difference in tumor SUV for survivors versus nonsurvivors.
The SUV correlates with prognostic indicators, such as tumor stage and grade. The SUV alone was not an independent predictor of survival. |
| doi_str_mv | 10.1016/j.amjsurg.2005.10.052 |
| format | article |
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A retrospective review of 187 patients undergoing PET for potential lung cancer. Data collected included patient demographics, tumor pathology, and survival information. Data were correlated with PET results to determine if a prognostic relationship exists.
The sensitivity and specificity of PET for detecting malignant lesions were 98% and 24%. Malignant lesions had a higher SUV than benign lesions (5.9 ± 6.2 versus 2.2 ± 1.8,
P < .0001). The average SUV of well-differentiated tumors was 2.6 ± 3.1 versus 5.9 ± 5.5 for other tumors (
P = .010). There was a strong correlation between tumor stage and SUV (analysis of variance,
P < .0001). There was no difference in tumor SUV for survivors versus nonsurvivors.
The SUV correlates with prognostic indicators, such as tumor stage and grade. The SUV alone was not an independent predictor of survival.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2005.10.052</identifier><identifier>PMID: 16490562</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Family medical history ; Female ; Humans ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Medical imaging ; Mortality ; Neoplasm Staging ; Patients ; PET scan ; Positron-Emission Tomography ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Staging ; Standard deviation ; Survival Rate ; Tobacco ; Tomography ; Tumors</subject><ispartof>The American journal of surgery, 2006-03, Vol.191 (3), p.433-436</ispartof><rights>2006 Excerpta Medica Inc.</rights><rights>Copyright Elsevier Limited Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-d9b4c08bed0fb0778d2ddc44b8ab4f8920650cfdafe2585ad31fce0ad4a598853</citedby><cites>FETCH-LOGICAL-c419t-d9b4c08bed0fb0778d2ddc44b8ab4f8920650cfdafe2585ad31fce0ad4a598853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16490562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kieninger, Alicia N.</creatorcontrib><creatorcontrib>Welsh, Robert</creatorcontrib><creatorcontrib>Bendick, Phillip J.</creatorcontrib><creatorcontrib>Zelenock, Gerald</creatorcontrib><creatorcontrib>Chmielewski, Gary W.</creatorcontrib><title>Positron-emission tomography as a prognostic tool for early-stage lung cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Positron-emission tomography (PET) shows tissue metabolic activity in the form of the standard uptake value (SUV). This study examines the prognostic value of the SUV for early-stage lung cancer.
A retrospective review of 187 patients undergoing PET for potential lung cancer. Data collected included patient demographics, tumor pathology, and survival information. Data were correlated with PET results to determine if a prognostic relationship exists.
The sensitivity and specificity of PET for detecting malignant lesions were 98% and 24%. Malignant lesions had a higher SUV than benign lesions (5.9 ± 6.2 versus 2.2 ± 1.8,
P < .0001). The average SUV of well-differentiated tumors was 2.6 ± 3.1 versus 5.9 ± 5.5 for other tumors (
P = .010). There was a strong correlation between tumor stage and SUV (analysis of variance,
P < .0001). There was no difference in tumor SUV for survivors versus nonsurvivors.
The SUV correlates with prognostic indicators, such as tumor stage and grade. The SUV alone was not an independent predictor of survival.</description><subject>Aged</subject><subject>Family medical history</subject><subject>Female</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>PET scan</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Staging</subject><subject>Standard deviation</subject><subject>Survival Rate</subject><subject>Tobacco</subject><subject>Tomography</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkU1r3DAQhkVpaDZpf0KLoZCbNyNZ8kqnEkK-ICE5tGchS2NXxra2kh3Yf18tu1DoIWEOYkbPzLzMS8hXCmsKtL7s12bs0xK7NQMQubYGwT6QFZUbVVIpq49kBQCsVDWFU3KWUp9TSnn1iZzSmisQNVuRp5eQ_BzDVOLoU_JhKuYwhi6a7e9dYVJhim0M3RTS7G3-CkPRhligicOuTLPpsBiWqSusmSzGz-SkNUPCL8f3nPy6vfl5fV8-Pt89XF89lpZTNZdONdyCbNBB28BmIx1zznLeSNPwVioGtQDbOtMiE1IYV9HWIhjHjVBSiuqcXBzmZm1_FkyzzuItDoOZMCxJ15t9KJrB7_-BfVjilLVpyjmvqVS8epOCijLKhJCZEgfKxpBSxFZvox9N3GVI7z3RvT56ovee7MvZk9z37Th9aUZ0_7qOJmTgxwHAfLJXj1En6zHf0_mIdtYu-HdW_AXSNKAJ</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Kieninger, Alicia N.</creator><creator>Welsh, Robert</creator><creator>Bendick, Phillip J.</creator><creator>Zelenock, Gerald</creator><creator>Chmielewski, Gary W.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Positron-emission tomography as a prognostic tool for early-stage lung cancer</title><author>Kieninger, Alicia N. ; 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This study examines the prognostic value of the SUV for early-stage lung cancer.
A retrospective review of 187 patients undergoing PET for potential lung cancer. Data collected included patient demographics, tumor pathology, and survival information. Data were correlated with PET results to determine if a prognostic relationship exists.
The sensitivity and specificity of PET for detecting malignant lesions were 98% and 24%. Malignant lesions had a higher SUV than benign lesions (5.9 ± 6.2 versus 2.2 ± 1.8,
P < .0001). The average SUV of well-differentiated tumors was 2.6 ± 3.1 versus 5.9 ± 5.5 for other tumors (
P = .010). There was a strong correlation between tumor stage and SUV (analysis of variance,
P < .0001). There was no difference in tumor SUV for survivors versus nonsurvivors.
The SUV correlates with prognostic indicators, such as tumor stage and grade. The SUV alone was not an independent predictor of survival.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16490562</pmid><doi>10.1016/j.amjsurg.2005.10.052</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Family medical history Female Humans Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical imaging Mortality Neoplasm Staging Patients PET scan Positron-Emission Tomography Prognosis Retrospective Studies Sensitivity and Specificity Staging Standard deviation Survival Rate Tobacco Tomography Tumors |
| title | Positron-emission tomography as a prognostic tool for early-stage lung cancer |
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