Paradoxical Contributions of Non-Compacted and Compacted Segments to Global Left Ventricular Dysfunction in Isolated Left Ventricular Noncompaction

The pathophysiologic mechanisms of left ventricular (LV) dysfunction in isolated ventricular noncompaction (IVNC) remain unclear. Evaluating global and segmental systolic LV function in 65 patients with IVNC, this study found that normal wall motion was more common in noncompacted than in compacted...

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Bibliographic Details
Published in:The American journal of cardiology 2006-03, Vol.97 (5), p.738-741
Main Authors: Lofiego, Carla, Biagini, Elena, Ferlito, Marinella, Pasquale, Ferdinando, Rocchi, Guido, Perugini, Enrica, Leone, Ornella, Bracchetti, Giovanni, Caliskan, Kadir, Branzi, Angelo, ten Cate, Folkert J., Rapezzi, Claudio
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular disease
Echocardiography, Doppler, Color
Female
Heart
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Male
Medical sciences
Middle Aged
Observer Variation
Stroke Volume
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - epidemiology
Ventricular Dysfunction, Left - pathology
Ventricular Dysfunction, Left - physiopathology
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Summary:The pathophysiologic mechanisms of left ventricular (LV) dysfunction in isolated ventricular noncompaction (IVNC) remain unclear. Evaluating global and segmental systolic LV function in 65 patients with IVNC, this study found that normal wall motion was more common in noncompacted than in compacted segments. The number of noncompacted segments per patient correlated positively with the LV ejection fraction and negatively with LV end-diastolic volume index. These paradoxical findings support the concept that noncompaction represents a marker of a more generalized (cardio)myopathy rather than the direct pathophysiologic substrate of this still little-understood disease.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.09.109