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l-arginine treatment early in life influences NADPH-diaphorase neurons in visual cortex of normal and early-malnourished adult rats
This study investigated the effects of repeated l-arginine administration during lactation, combined with different suckling conditions, on morphometric parameters of primary visual cortex NADPH-diaphorase-positive neurons. Wistar rat pups reared in “normal-size litters” or “large litters” (N- and L...
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| Published in: | Brain research 2006-02, Vol.1072 (1), p.19-25 |
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| cites | cdi_FETCH-LOGICAL-c427t-71a2d43eee43d1e5a920646b9cb527aa22ef0955677702b4a19e8623c869bf103 |
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| container_title | Brain research |
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| creator | Maia, Luciana M.S.S. Frazão, Marília F. Souza, Thays K.M. Silva, Mariana B. Rocha-de-Melo, Ana P. Picanço-Diniz, Cristovam W. Amâncio-dos-Santos, Ângela Guedes, Rubem C.A. |
| description | This study investigated the effects of repeated
l-arginine administration during lactation, combined with different suckling conditions, on morphometric parameters of primary visual cortex NADPH-diaphorase-positive neurons. Wistar rat pups reared in “normal-size litters” or “large litters” (N- and L-conditions; litters formed by 6 and 12 pups, respectively) received, from postnatal day 7 to 28, either arginine (300 mg/kg/day, per gavage) or distilled water (control). At 90–120 days of life, they were perfused with saline + formaldehyde, and their brains were processed for histochemical reaction to reveal NADPH-diaphorase-positive neurons (malic enzyme indirect method). Compared to the normal-size litters, L-rats had lower body weights (
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| doi_str_mv | 10.1016/j.brainres.2005.12.027 |
| format | article |
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l-arginine administration during lactation, combined with different suckling conditions, on morphometric parameters of primary visual cortex NADPH-diaphorase-positive neurons. Wistar rat pups reared in “normal-size litters” or “large litters” (N- and L-conditions; litters formed by 6 and 12 pups, respectively) received, from postnatal day 7 to 28, either arginine (300 mg/kg/day, per gavage) or distilled water (control). At 90–120 days of life, they were perfused with saline + formaldehyde, and their brains were processed for histochemical reaction to reveal NADPH-diaphorase-positive neurons (malic enzyme indirect method). Compared to the normal-size litters, L-rats had lower body weights (
P < 0.05), confirming the effectiveness of the L-condition in affecting pup development. Concerning NADPH-d histochemistry, arginine treatment was associated with increased (
P < 0.05) density of dendrite varicosities and of dendrite branching frequency, suggesting a plastic response of the developing brain to that treatment, even in previously malnourished rats. No difference was seen, however, in dendrite orientation, total number of neurons, soma area and perimeter, as well as dendrite bifurcation points, fractal dimension, and area and volume of dendrite field, suggesting that NADPH-d cells are resistant to arginine and nutritional changes, regarding these features. Data are considered of interest for studies of synaptic plasticity during neural development and its relationships to aggressive agents like malnutrition.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2005.12.027</identifier><identifier>PMID: 16426587</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Arginine ; Arginine - pharmacology ; Biological and medical sciences ; Body Weight ; Brain - growth & development ; Eye and associated structures. Visual pathways and centers. Vision ; Female ; Fundamental and applied biological sciences. Psychology ; Lactation ; Malnutrition ; Malnutrition - physiopathology ; NADPH Dehydrogenase - metabolism ; NADPH-diaphorase ; Neurons - drug effects ; Neurons - physiology ; Nitric oxide ; Organ Size ; Rats ; Rats, Wistar ; Reference Values ; Vertebrates: nervous system and sense organs ; Visual cortex ; Visual Cortex - drug effects ; Visual Cortex - physiology</subject><ispartof>Brain research, 2006-02, Vol.1072 (1), p.19-25</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-71a2d43eee43d1e5a920646b9cb527aa22ef0955677702b4a19e8623c869bf103</citedby><cites>FETCH-LOGICAL-c427t-71a2d43eee43d1e5a920646b9cb527aa22ef0955677702b4a19e8623c869bf103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17557110$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16426587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maia, Luciana M.S.S.</creatorcontrib><creatorcontrib>Frazão, Marília F.</creatorcontrib><creatorcontrib>Souza, Thays K.M.</creatorcontrib><creatorcontrib>Silva, Mariana B.</creatorcontrib><creatorcontrib>Rocha-de-Melo, Ana P.</creatorcontrib><creatorcontrib>Picanço-Diniz, Cristovam W.</creatorcontrib><creatorcontrib>Amâncio-dos-Santos, Ângela</creatorcontrib><creatorcontrib>Guedes, Rubem C.A.</creatorcontrib><title>l-arginine treatment early in life influences NADPH-diaphorase neurons in visual cortex of normal and early-malnourished adult rats</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>This study investigated the effects of repeated
l-arginine administration during lactation, combined with different suckling conditions, on morphometric parameters of primary visual cortex NADPH-diaphorase-positive neurons. Wistar rat pups reared in “normal-size litters” or “large litters” (N- and L-conditions; litters formed by 6 and 12 pups, respectively) received, from postnatal day 7 to 28, either arginine (300 mg/kg/day, per gavage) or distilled water (control). At 90–120 days of life, they were perfused with saline + formaldehyde, and their brains were processed for histochemical reaction to reveal NADPH-diaphorase-positive neurons (malic enzyme indirect method). Compared to the normal-size litters, L-rats had lower body weights (
P < 0.05), confirming the effectiveness of the L-condition in affecting pup development. Concerning NADPH-d histochemistry, arginine treatment was associated with increased (
P < 0.05) density of dendrite varicosities and of dendrite branching frequency, suggesting a plastic response of the developing brain to that treatment, even in previously malnourished rats. No difference was seen, however, in dendrite orientation, total number of neurons, soma area and perimeter, as well as dendrite bifurcation points, fractal dimension, and area and volume of dendrite field, suggesting that NADPH-d cells are resistant to arginine and nutritional changes, regarding these features. Data are considered of interest for studies of synaptic plasticity during neural development and its relationships to aggressive agents like malnutrition.</description><subject>Animals</subject><subject>Arginine</subject><subject>Arginine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Brain - growth & development</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lactation</subject><subject>Malnutrition</subject><subject>Malnutrition - physiopathology</subject><subject>NADPH Dehydrogenase - metabolism</subject><subject>NADPH-diaphorase</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Nitric oxide</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reference Values</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual cortex</subject><subject>Visual Cortex - drug effects</subject><subject>Visual Cortex - physiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EokvhL1S-wC3BdhI7uVGVjyJVwAHO1sSZUK8cexknFT3zx0nYRT32NBrrecdjP4xdSFFKIfXbfdkT-EiYSyVEU0pVCmWesJ1sjSq0qsVTthNC6KLtuuqMvch5v7ZV1Ynn7EzqWummNTv2JxRAP330EflMCPOEceYIFO65jzz4Edc6hgWjw8y_XL7_dl0MHg63iSAjj7hQinlj73xeIHCXaMbfPI08JprWA4jDcWCxdjEt5PMtDhyGJcycYM4v2bMRQsZXp3rOfnz88P3qurj5-unz1eVN4Wpl5sJIUENdIWJdDRIb6JTQte471zfKACiFo-iaRhtjhOprkB22WlWu1V0_SlGdszfHuQdKvxbMs518dhgCRExLttpos-UfBaWRou2MWkF9BB2lnAlHeyA_Ad1bKezmye7tf09282SlsqunNXhxumHpJxweYicxK_D6BEB2EEaC6Hx-4EzTGPnvTe-OHK4fd-eRbHZ-czV4QjfbIfnHdvkLECi2DA</recordid><startdate>20060209</startdate><enddate>20060209</enddate><creator>Maia, Luciana M.S.S.</creator><creator>Frazão, Marília F.</creator><creator>Souza, Thays K.M.</creator><creator>Silva, Mariana B.</creator><creator>Rocha-de-Melo, Ana P.</creator><creator>Picanço-Diniz, Cristovam W.</creator><creator>Amâncio-dos-Santos, Ângela</creator><creator>Guedes, Rubem C.A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060209</creationdate><title>l-arginine treatment early in life influences NADPH-diaphorase neurons in visual cortex of normal and early-malnourished adult rats</title><author>Maia, Luciana M.S.S. ; Frazão, Marília F. ; Souza, Thays K.M. ; Silva, Mariana B. ; Rocha-de-Melo, Ana P. ; Picanço-Diniz, Cristovam W. ; Amâncio-dos-Santos, Ângela ; Guedes, Rubem C.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-71a2d43eee43d1e5a920646b9cb527aa22ef0955677702b4a19e8623c869bf103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Arginine</topic><topic>Arginine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Brain - growth & development</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lactation</topic><topic>Malnutrition</topic><topic>Malnutrition - physiopathology</topic><topic>NADPH Dehydrogenase - metabolism</topic><topic>NADPH-diaphorase</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Nitric oxide</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reference Values</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual cortex</topic><topic>Visual Cortex - drug effects</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maia, Luciana M.S.S.</creatorcontrib><creatorcontrib>Frazão, Marília F.</creatorcontrib><creatorcontrib>Souza, Thays K.M.</creatorcontrib><creatorcontrib>Silva, Mariana B.</creatorcontrib><creatorcontrib>Rocha-de-Melo, Ana P.</creatorcontrib><creatorcontrib>Picanço-Diniz, Cristovam W.</creatorcontrib><creatorcontrib>Amâncio-dos-Santos, Ângela</creatorcontrib><creatorcontrib>Guedes, Rubem C.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maia, Luciana M.S.S.</au><au>Frazão, Marília F.</au><au>Souza, Thays K.M.</au><au>Silva, Mariana B.</au><au>Rocha-de-Melo, Ana P.</au><au>Picanço-Diniz, Cristovam W.</au><au>Amâncio-dos-Santos, Ângela</au><au>Guedes, Rubem C.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>l-arginine treatment early in life influences NADPH-diaphorase neurons in visual cortex of normal and early-malnourished adult rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2006-02-09</date><risdate>2006</risdate><volume>1072</volume><issue>1</issue><spage>19</spage><epage>25</epage><pages>19-25</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>This study investigated the effects of repeated
l-arginine administration during lactation, combined with different suckling conditions, on morphometric parameters of primary visual cortex NADPH-diaphorase-positive neurons. Wistar rat pups reared in “normal-size litters” or “large litters” (N- and L-conditions; litters formed by 6 and 12 pups, respectively) received, from postnatal day 7 to 28, either arginine (300 mg/kg/day, per gavage) or distilled water (control). At 90–120 days of life, they were perfused with saline + formaldehyde, and their brains were processed for histochemical reaction to reveal NADPH-diaphorase-positive neurons (malic enzyme indirect method). Compared to the normal-size litters, L-rats had lower body weights (
P < 0.05), confirming the effectiveness of the L-condition in affecting pup development. Concerning NADPH-d histochemistry, arginine treatment was associated with increased (
P < 0.05) density of dendrite varicosities and of dendrite branching frequency, suggesting a plastic response of the developing brain to that treatment, even in previously malnourished rats. No difference was seen, however, in dendrite orientation, total number of neurons, soma area and perimeter, as well as dendrite bifurcation points, fractal dimension, and area and volume of dendrite field, suggesting that NADPH-d cells are resistant to arginine and nutritional changes, regarding these features. Data are considered of interest for studies of synaptic plasticity during neural development and its relationships to aggressive agents like malnutrition.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>16426587</pmid><doi>10.1016/j.brainres.2005.12.027</doi><tpages>7</tpages></addata></record> |
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| source | ScienceDirect Journals |
| subjects | Animals Arginine Arginine - pharmacology Biological and medical sciences Body Weight Brain - growth & development Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Lactation Malnutrition Malnutrition - physiopathology NADPH Dehydrogenase - metabolism NADPH-diaphorase Neurons - drug effects Neurons - physiology Nitric oxide Organ Size Rats Rats, Wistar Reference Values Vertebrates: nervous system and sense organs Visual cortex Visual Cortex - drug effects Visual Cortex - physiology |
| title | l-arginine treatment early in life influences NADPH-diaphorase neurons in visual cortex of normal and early-malnourished adult rats |
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