Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results

Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile. We sought to determine whether the addition of a statin with sildenafil would improve...

Full description

Saved in:
Bibliographic Details
Published in:Journal of sexual medicine 2006-03, Vol.3 (2), p.303-308
Main Authors: Herrmann, Howard C, Levine, Laurence A, Macaluso, Jr, Joseph, Walsh, Michelle, Bradbury, Danielle, Schwartz, Stanley, Mohler, 3rd, Emile R, Kimmel, Stephen E
Format: Article
Language:English
Subjects:
Adult
Aged
Anticholesteremic Agents - administration & dosage
Atorvastatin Calcium
Cholesterol, LDL - metabolism
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Erectile Dysfunction - drug therapy
Heptanoic Acids - administration & dosage
Humans
Male
Middle Aged
Penile Erection - drug effects
Pilot Projects
Piperazines - administration & dosage
Purines
Pyrroles - administration & dosage
Sildenafil Citrate
Sulfones
Treatment Outcome
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Erectile dysfunction (ED) may be one manifestation of a generalized vascular disorder characterized by endothelial dysfunction. Statin drugs may improve endothelial function, even before altering the lipid profile. We sought to determine whether the addition of a statin with sildenafil would improve ED in men who initially responded poorly to sildenafil. Men with moderate-to-severe ED despite an adequate sildenafil trial were enrolled in this randomized, double-blind, placebo-controlled pilot study. ED was defined using a validated self-administered questionnaire as a score of
ISSN:1743-6095
DOI:10.1111/j.1743-6109.2005.00156.x