The predictive value of incidental PET/CT findings suspicious for breast cancer in women with non-breast malignancies

Abstract Background On occasion, patients followed with positron emission tomographic (PET)/computed tomographic (CT) imaging for nonbreast malignancies will have incidental breast findings concerning for second primary breast cancers. The aim of this study was to determine the predictive value of P...

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Bibliographic Details
Published in:The American journal of surgery 2009-10, Vol.198 (4), p.495-499
Main Authors: Beatty, John S., M.D, Williams, Hadyn T., M.D, Gucwa, Angela L., M.D, Hughes, Matthew P., B.S, Vasudeva, Viren S., B.A, Aldridge, Beau A., B.S, Fields, Deborah M., C.N.M.T., M.Ed, David, George S., M.S, Lind, D. Scott, M.D, Kruse, E. James, D.O, McLoughlin, James M., M.D
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Biological and medical sciences
Breast cancer
Breast Neoplasms - diagnosis
Cancer
Computed tomography
Disease
Female
General aspects
Gynecology. Andrology. Obstetrics
Humans
Imaging
Incidental Findings
Mammary gland diseases
Mammography
Mass Screening
Medical sciences
Medical screening
Metabolism
Middle Aged
Neoplasms, Second Primary - diagnosis
Nuclear medicine
Patients
PET/CT
Positron emission
Positron-Emission Tomography
Predictive Value of Tests
Review boards
Second primary malignancy
Studies
Surgery
Surveillance
Thyroid gland
Tomography, X-Ray Computed
Tumors
Womens health
Young Adult
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Summary:Abstract Background On occasion, patients followed with positron emission tomographic (PET)/computed tomographic (CT) imaging for nonbreast malignancies will have incidental breast findings concerning for second primary breast cancers. The aim of this study was to determine the predictive value of PET/CT imaging to identify breast cancers in these patients. Methods Patients with primary nonbreast malignancies and findings concerning for second primary breast cancers were identified from a prospectively acquired nuclear medicine database from January 2005 to July 2008. Chart reviews were then performed. Results Nine hundred two women underwent PET/CT imaging to evaluate nonbreast malignancies. Nine women (1%) had concerning breast findings, and 5 (56%) had subsequent breast cancer diagnoses. The positive predictive value of PET/CT imaging in these patients was 63%. Evidence of compliance with current screening guidelines was present in only 22% of these patients. Conclusions The data suggest that findings concerning for an additional primary breast cancer should be evaluated and that age-appropriate screening tools should not be abandoned.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2009.06.009