Gene-chip analysis of the effect of tripeptide tyroservatide (YSV) on gene-expression in human hepatocarcinoma BEL-7402 tumors transplanted to nude mice

Tyroservatide (YSV) is a bioactive tripeptide of tyrosyl‐seryl‐valine. In this study, we studied the effects of YSV on human hepatocarcinoma BEL‐7402 tumors transplanted in BALB/c (nu/nu) nude mice, and gene expression in the tumor cells with gene‐chip analysis. Results show that YSV significantly i...

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Bibliographic Details
Published in:Molecular carcinogenesis 2006-03, Vol.45 (3), p.197-203
Main Authors: Jia, Jing, Lu, Rong, Zhou, Chunlei, Zhao, Lan, Fu, Zheng, Zhu, Zhitong, Wang, Li, Zheng, Minna, Yang, Jing, Zhang, Yanjun, Yao, Zhi
Format: Article
Language:English
Subjects:
Animals
antitumor
Carcinoma, Hepatocellular - genetics
DNA Primers
Gene Expression Regulation, Neoplastic - drug effects
gene-chip
histone
Humans
Liver Neoplasms - genetics
Mice
Mice, Inbred BALB C
Mice, Nude
nude mice
Oligonucleotide Array Sequence Analysis
Oligopeptides - pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Transplantation, Heterologous
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Summary:Tyroservatide (YSV) is a bioactive tripeptide of tyrosyl‐seryl‐valine. In this study, we studied the effects of YSV on human hepatocarcinoma BEL‐7402 tumors transplanted in BALB/c (nu/nu) nude mice, and gene expression in the tumor cells with gene‐chip analysis. Results show that YSV significantly inhibits the growth of transplanted human hepatocarcinoma BEL‐7402 in nude mice (n = 12) compared with the control group (P 
ISSN:0899-1987
1098-2744
DOI:10.1002/mc.20172