Acute renal failure in African children with Burkitt's lymphoma: A comparison of two treatment regimens

• Published in: Pediatric Blood & Cancer 2006-04, Vol.46 (4), p.446-453
• Main Authors: Olowu, Wasiu A., Elusiyan, Jerome B.E., Badejo, Sekinat A., Adenowo, Olusola A.
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - complications; Acute Kidney Injury - drug therapy; Adolescent; Africa; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Burkitt Lymphoma - complications; Burkitt Lymphoma - drug therapy; Child; Child, Preschool; cyclophosphamide infusion; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; General aspects; Humans; Male; Medical sciences; oligoanuria; Retrospective Studies; Treatment Outcome; tumor lysis syndrome; Tumors
• ISSN: 1545-5009; 1545-5017; 1096-911X
• DOI: 10.1002/pbc.20473

Background The outcome for patients presenting with acute renal failure and Burkitt lymphoma (BLARF) without dialysis is poor. This was a retrospective non‐randomized comparative study designed to determine the outcome of two different treatment protocols. Methods One group of patients (TPA) received oral allopurinol, intravenous (IV) cyclophosphamide, vincristine, methotrexate, furosemide, 8.4% sodium bicarbonate, and intrathecal (IT) methotrexate; the other (TPB) alternate day IV infusion of low dose cyclosphosphamide (125 mg/m2 × 4 doses), IT methotrexate (Days 1 and 5) and aggressive pre‐emptive anti‐tumor lysis syndrome therapy including oral allopurinol and calcium lactate, IV calcium gluconate, salbutamol, insulin and infusions of furosemide, sodium bicarbonate and glucose. Results Nine of 16 received TPA, 7 received TPB. Post chemotherapy anemia was more severe with TPA (P