Peptide-based Molecules in Angiogenesis

Angiogenesis refers to the process of remodeling the vascular tissue characterized by the branching out of a new blood vessel from a pre‐existing vessel. Angiogenesis is particularly active during embryogenesis, while during adult life it is quiescent and limited to particular physiologic phenomena....

Full description

Saved in:
Bibliographic Details
Published in:Chemical biology & drug design 2006-02, Vol.67 (2), p.115-126
Main Authors: D'Andrea, Luca Domenico, Del Gatto, Annarita, Pedone, Carlo, Benedetti, Ettore
Format: Article
Language:English
Subjects:
angiogenesis
Animals
cancer
Drug Design
Humans
integrins
Integrins - antagonists & inhibitors
Integrins - metabolism
ischemia
Neoplasms - blood supply
Neoplasms - drug therapy
Neoplasms - pathology
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
peptide
Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors
Receptors, Vascular Endothelial Growth Factor - metabolism
Structure-Activity Relationship
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Vascular Endothelial Growth Factor A - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Angiogenesis refers to the process of remodeling the vascular tissue characterized by the branching out of a new blood vessel from a pre‐existing vessel. Angiogenesis is particularly active during embryogenesis, while during adult life it is quiescent and limited to particular physiologic phenomena. Recently, the study of molecular mechanisms of angiogenesis has stirred renewed interest due to the recognition of the role played by angiogenesis in several pathologies of significant medical impact, such as cancer and cardiovascular disease, and due to the pharmacologic interest rising from the possibility of modulating these phenomena. Antibodies, peptides and small molecules targeting active endothelial cells represent an innovative tool in therapeutic and diagnostic fields. In this study, we reviewed the literature of peptide and peptidomimetics in angiogenesis and their potential applications. Two specific protein systems, namely the vascular endothelial growth factor and its receptor and integrins, will be discussed in detail.
ISSN:1747-0277
1747-0285
DOI:10.1111/j.1747-0285.2006.00356.x