A Chemogenomic Approach to Discovering Target-Selective Drugs

An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high‐quality high‐throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from ‘hi...

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Bibliographic Details
Published in:Chemical biology & drug design 2006-01, Vol.67 (1), p.85-86
Main Authors: Janzen, William P., Hodge, C. Nicholas
Format: Article
Language:English
Subjects:
Chemistry, Pharmaceutical - methods
Databases, Protein
Drug Design
Structure-Activity Relationship
Technology, Pharmaceutical
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Summary:An approach is described for identifying scaffolds with predefined selectivity profiles directly from a high‐quality high‐throughput screening data set, and monitoring that selectivity profile throughout the drug discovery process. This approach results in reduced drug development timelines from ‘hit’ to ‘lead’ stage, and should reduce liabilities for a molecule advancing through the development process.
ISSN:1747-0277
1747-0285
DOI:10.1111/j.1747-0285.2005.00325.x