Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts

The authors examined the association of gestational hypertensive disorders (hypertension, preeclampsia, eclampsia) with adult cognitive function among men born in 1978–1983 in a well-defined geographic area of northern Denmark. Data from the Danish Medical Birth Registry, the Danish National Registr...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 2009-10, Vol.170 (8), p.1025-1031
Main Authors: Ehrenstein, Vera, Rothman, Kenneth J., Pedersen, Lars, Hatch, Elizabeth E., Sørensen, Henrik Toft
Format: Article
Language:English
Subjects:
Adult
Analysis. Health state
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cognition
Cognition & reasoning
Denmark
Diseases of mother, fetus and pregnancy
Epidemiology
Female
Follow-Up Studies
General aspects
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Hypertension
Hypertension, Pregnancy-Induced
Infant, Newborn
Infant, Small for Gestational Age
Intelligence
Intelligence Tests
Male
Maternal & child health
Medical sciences
Military Personnel
pre-eclampsia
Pregnancy
Pregnancy. Fetus. Placenta
Public health. Hygiene
Public health. Hygiene-occupational medicine
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3
cites cdi_FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3
container_end_page 1031
container_issue 8
container_start_page 1025
container_title American journal of epidemiology
container_volume 170
creator Ehrenstein, Vera
Rothman, Kenneth J.
Pedersen, Lars
Hatch, Elizabeth E.
Sørensen, Henrik Toft
description The authors examined the association of gestational hypertensive disorders (hypertension, preeclampsia, eclampsia) with adult cognitive function among men born in 1978–1983 in a well-defined geographic area of northern Denmark. Data from the Danish Medical Birth Registry, the Danish National Registry of Patients, and draft board records were linked. Cognitive function was measured at conscription by using the Boerge Prien group intelligence test. Test scores were converted to the conventional IQ scale (mean = 100 (standard deviation, 15)). Low cognitive function was defined as IQ
doi_str_mv 10.1093/aje/kwp223
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67684111</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/aje/kwp223</oup_id><sourcerecordid>21138228</sourcerecordid><originalsourceid>FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3</originalsourceid><addsrcrecordid>eNqF0U1v1DAQBmALgehSuPADUIQEB6RQf8WJj9vdlgVVAqlFIC7GcSaLt1k72E5h_z2udtVKHOA0h3k8o_GL0HOC3xIs2YnewMn1r5FS9gDNCK9FKWglHqIZxpiWkgp6hJ7EuMGYEFnhx-iIyJoKLqsZ-v4pwNppZ3aljtEbqxN0xWo3Qkjgor2BYmmjDx2EWGjXFfNuGlKx8Gtn0233fHImWe-K-da7dbHUzsYfue-iCXZM8Sl61OshwrNDPUafz8-uFqvy4uO794v5RWkqzlLJsTQtwZ3pGMZVTzAGCY0QvTRdC3VLWkaozFa0vWA9r3mbn0AjCRdQmZYdo9f7uWPwPyeISW1tNDAM2oGfohK1aDgh5L-QZtNQ2mT48i-48VNw-QhFWdUIzpnI6M0emeBjDNCrMditDjtFsLpNR-V01D6djF8cJk7tFrp7eogjg1cHoKPRQx9yMDbeOUoxlvmKe-en8d8Ly72zMcHvO6nDdf4PVldq9fWb-nC5uLxqTr-oJfsD8560cA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>235864436</pqid></control><display><type>article</type><title>Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts</title><source>Oxford Journals Online</source><creator>Ehrenstein, Vera ; Rothman, Kenneth J. ; Pedersen, Lars ; Hatch, Elizabeth E. ; Sørensen, Henrik Toft</creator><creatorcontrib>Ehrenstein, Vera ; Rothman, Kenneth J. ; Pedersen, Lars ; Hatch, Elizabeth E. ; Sørensen, Henrik Toft</creatorcontrib><description>The authors examined the association of gestational hypertensive disorders (hypertension, preeclampsia, eclampsia) with adult cognitive function among men born in 1978–1983 in a well-defined geographic area of northern Denmark. Data from the Danish Medical Birth Registry, the Danish National Registry of Patients, and draft board records were linked. Cognitive function was measured at conscription by using the Boerge Prien group intelligence test. Test scores were converted to the conventional IQ scale (mean = 100 (standard deviation, 15)). Low cognitive function was defined as IQ &lt;85. Of the 17,457 men who underwent intelligence testing, 891 (5.1%) were born after a pregnancy involving hospitalization for a gestational hypertensive disorder. Compared with conscripts born after normotensive pregnancy, conscripts exposed to maternal gestational hypertension had an adjusted prevalence ratio for low cognitive function of 1.34 (95% confidence interval (CI): 1.01, 1.77). For those exposed to mild preeclampsia and severe preeclampsia/eclampsia, adjusted prevalence ratios were 1.34 (95% CI: 1.09, 1.65) and 1.10 (95% CI: 0.48, 2.51), respectively. The corresponding adjusted mean differences in IQ scores were −2.0 (95% CI: −4.0, 0.0), −3.2 (95% CI: −4.7, −1.8), and −2.0 (95% CI: −7.2, 3.2). In this study, prenatal exposure to gestational hypertensive disorders was associated with slightly reduced adult cognitive performance among male conscripts.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwp223</identifier><identifier>PMID: 19726495</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Analysis. Health state ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cognition ; Cognition &amp; reasoning ; Denmark ; Diseases of mother, fetus and pregnancy ; Epidemiology ; Female ; Follow-Up Studies ; General aspects ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Hypertension ; Hypertension, Pregnancy-Induced ; Infant, Newborn ; Infant, Small for Gestational Age ; Intelligence ; Intelligence Tests ; Male ; Maternal &amp; child health ; Medical sciences ; Military Personnel ; pre-eclampsia ; Pregnancy ; Pregnancy. Fetus. Placenta ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Young Adult</subject><ispartof>American journal of epidemiology, 2009-10, Vol.170 (8), p.1025-1031</ispartof><rights>American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2009</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Oct 15, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3</citedby><cites>FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=22009841$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19726495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehrenstein, Vera</creatorcontrib><creatorcontrib>Rothman, Kenneth J.</creatorcontrib><creatorcontrib>Pedersen, Lars</creatorcontrib><creatorcontrib>Hatch, Elizabeth E.</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><title>Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>The authors examined the association of gestational hypertensive disorders (hypertension, preeclampsia, eclampsia) with adult cognitive function among men born in 1978–1983 in a well-defined geographic area of northern Denmark. Data from the Danish Medical Birth Registry, the Danish National Registry of Patients, and draft board records were linked. Cognitive function was measured at conscription by using the Boerge Prien group intelligence test. Test scores were converted to the conventional IQ scale (mean = 100 (standard deviation, 15)). Low cognitive function was defined as IQ &lt;85. Of the 17,457 men who underwent intelligence testing, 891 (5.1%) were born after a pregnancy involving hospitalization for a gestational hypertensive disorder. Compared with conscripts born after normotensive pregnancy, conscripts exposed to maternal gestational hypertension had an adjusted prevalence ratio for low cognitive function of 1.34 (95% confidence interval (CI): 1.01, 1.77). For those exposed to mild preeclampsia and severe preeclampsia/eclampsia, adjusted prevalence ratios were 1.34 (95% CI: 1.09, 1.65) and 1.10 (95% CI: 0.48, 2.51), respectively. The corresponding adjusted mean differences in IQ scores were −2.0 (95% CI: −4.0, 0.0), −3.2 (95% CI: −4.7, −1.8), and −2.0 (95% CI: −7.2, 3.2). In this study, prenatal exposure to gestational hypertensive disorders was associated with slightly reduced adult cognitive performance among male conscripts.</description><subject>Adult</subject><subject>Analysis. Health state</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cognition</subject><subject>Cognition &amp; reasoning</subject><subject>Denmark</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pregnancy-Induced</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age</subject><subject>Intelligence</subject><subject>Intelligence Tests</subject><subject>Male</subject><subject>Maternal &amp; child health</subject><subject>Medical sciences</subject><subject>Military Personnel</subject><subject>pre-eclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Young Adult</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqF0U1v1DAQBmALgehSuPADUIQEB6RQf8WJj9vdlgVVAqlFIC7GcSaLt1k72E5h_z2udtVKHOA0h3k8o_GL0HOC3xIs2YnewMn1r5FS9gDNCK9FKWglHqIZxpiWkgp6hJ7EuMGYEFnhx-iIyJoKLqsZ-v4pwNppZ3aljtEbqxN0xWo3Qkjgor2BYmmjDx2EWGjXFfNuGlKx8Gtn0233fHImWe-K-da7dbHUzsYfue-iCXZM8Sl61OshwrNDPUafz8-uFqvy4uO794v5RWkqzlLJsTQtwZ3pGMZVTzAGCY0QvTRdC3VLWkaozFa0vWA9r3mbn0AjCRdQmZYdo9f7uWPwPyeISW1tNDAM2oGfohK1aDgh5L-QZtNQ2mT48i-48VNw-QhFWdUIzpnI6M0emeBjDNCrMditDjtFsLpNR-V01D6djF8cJk7tFrp7eogjg1cHoKPRQx9yMDbeOUoxlvmKe-en8d8Ly72zMcHvO6nDdf4PVldq9fWb-nC5uLxqTr-oJfsD8560cA</recordid><startdate>20091015</startdate><enddate>20091015</enddate><creator>Ehrenstein, Vera</creator><creator>Rothman, Kenneth J.</creator><creator>Pedersen, Lars</creator><creator>Hatch, Elizabeth E.</creator><creator>Sørensen, Henrik Toft</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7X8</scope></search><sort><creationdate>20091015</creationdate><title>Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts</title><author>Ehrenstein, Vera ; Rothman, Kenneth J. ; Pedersen, Lars ; Hatch, Elizabeth E. ; Sørensen, Henrik Toft</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Analysis. Health state</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cognition</topic><topic>Cognition &amp; reasoning</topic><topic>Denmark</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pregnancy-Induced</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age</topic><topic>Intelligence</topic><topic>Intelligence Tests</topic><topic>Male</topic><topic>Maternal &amp; child health</topic><topic>Medical sciences</topic><topic>Military Personnel</topic><topic>pre-eclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehrenstein, Vera</creatorcontrib><creatorcontrib>Rothman, Kenneth J.</creatorcontrib><creatorcontrib>Pedersen, Lars</creatorcontrib><creatorcontrib>Hatch, Elizabeth E.</creatorcontrib><creatorcontrib>Sørensen, Henrik Toft</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ehrenstein, Vera</au><au>Rothman, Kenneth J.</au><au>Pedersen, Lars</au><au>Hatch, Elizabeth E.</au><au>Sørensen, Henrik Toft</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2009-10-15</date><risdate>2009</risdate><volume>170</volume><issue>8</issue><spage>1025</spage><epage>1031</epage><pages>1025-1031</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>The authors examined the association of gestational hypertensive disorders (hypertension, preeclampsia, eclampsia) with adult cognitive function among men born in 1978–1983 in a well-defined geographic area of northern Denmark. Data from the Danish Medical Birth Registry, the Danish National Registry of Patients, and draft board records were linked. Cognitive function was measured at conscription by using the Boerge Prien group intelligence test. Test scores were converted to the conventional IQ scale (mean = 100 (standard deviation, 15)). Low cognitive function was defined as IQ &lt;85. Of the 17,457 men who underwent intelligence testing, 891 (5.1%) were born after a pregnancy involving hospitalization for a gestational hypertensive disorder. Compared with conscripts born after normotensive pregnancy, conscripts exposed to maternal gestational hypertension had an adjusted prevalence ratio for low cognitive function of 1.34 (95% confidence interval (CI): 1.01, 1.77). For those exposed to mild preeclampsia and severe preeclampsia/eclampsia, adjusted prevalence ratios were 1.34 (95% CI: 1.09, 1.65) and 1.10 (95% CI: 0.48, 2.51), respectively. The corresponding adjusted mean differences in IQ scores were −2.0 (95% CI: −4.0, 0.0), −3.2 (95% CI: −4.7, −1.8), and −2.0 (95% CI: −7.2, 3.2). In this study, prenatal exposure to gestational hypertensive disorders was associated with slightly reduced adult cognitive performance among male conscripts.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>19726495</pmid><doi>10.1093/aje/kwp223</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0002-9262
ispartof American journal of epidemiology, 2009-10, Vol.170 (8), p.1025-1031
issn 0002-9262
1476-6256
language eng
recordid cdi_proquest_miscellaneous_67684111
source Oxford Journals Online
subjects Adult
Analysis. Health state
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cognition
Cognition & reasoning
Denmark
Diseases of mother, fetus and pregnancy
Epidemiology
Female
Follow-Up Studies
General aspects
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Hypertension
Hypertension, Pregnancy-Induced
Infant, Newborn
Infant, Small for Gestational Age
Intelligence
Intelligence Tests
Male
Maternal & child health
Medical sciences
Military Personnel
pre-eclampsia
Pregnancy
Pregnancy. Fetus. Placenta
Public health. Hygiene
Public health. Hygiene-occupational medicine
Young Adult
title Pregnancy-associated Hypertensive Disorders and Adult Cognitive Function Among Danish Conscripts
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T17%3A42%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pregnancy-associated%20Hypertensive%20Disorders%20and%20Adult%20Cognitive%20Function%20Among%20Danish%20Conscripts&rft.jtitle=American%20journal%20of%20epidemiology&rft.au=Ehrenstein,%20Vera&rft.date=2009-10-15&rft.volume=170&rft.issue=8&rft.spage=1025&rft.epage=1031&rft.pages=1025-1031&rft.issn=0002-9262&rft.eissn=1476-6256&rft.coden=AJEPAS&rft_id=info:doi/10.1093/aje/kwp223&rft_dat=%3Cproquest_cross%3E21138228%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c543t-409cb10dcd3005f100e9e866f9cdbe7b1b3129c546bf63f474b409e89146e5cb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=235864436&rft_id=info:pmid/19726495&rft_oup_id=10.1093/aje/kwp223&rfr_iscdi=true