New chiral stationary phase with macrocyclic glycopeptide antibiotic eremomycin chemically bonded to silica

A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enan...

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Bibliographic Details
Published in:Journal of Chromatography A 2006-03, Vol.1108 (2), p.263-267
Main Authors: Staroverov, S.M., Kuznetsov, M.A., Nesterenko, P.N., Vasiarov, G.G., Katrukha, G.S., Fedorova, G.B.
Format: Article
Language:English
Subjects:
Amino acids
Anti-Bacterial Agents - chemistry
Chiral stationary phases
Enantiomeric separations
Eremomycin
Glycopeptides - chemistry
Macrocyclic glycopeptide antibiotics
Ristocetin A
Silicon Dioxide - chemistry
Stereoisomerism
Vancomycin
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Summary:A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of ristocetin A CSP that method of the immobilization of macrocyclic glycopeptide antibiotics affects remarkably the resulting enantioselectivity.
ISSN:0021-9673
DOI:10.1016/j.chroma.2006.01.073