Neuralized-2: Expression in human and rodents and interaction with Delta-like ligands

Delta–Notch signaling is a universal cell–cell communication pathway crucial for numerous developmental and physiological processes. Several proteins interact with and regulate the Notch pathway, including the E3 ubiquitin ligase Neuralized (Neur) that influences the stability and activity of Notch...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2009-11, Vol.389 (3), p.420-425
Main Authors: Rullinkov, Grete, Tamme, Richard, Sarapuu, Anzelika, Laurén, Juha, Sepp, Mari, Palm, Kaia, Timmusk, Tõnis
Format: Article
Language:English
Subjects:
Animals
Brain - embryology
Brain - enzymology
Delta
Hippocampus - cytology
Hippocampus - embryology
Hippocampus - enzymology
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Ligands
Membrane Proteins - metabolism
Mice
Muscle Proteins - genetics
Muscle Proteins - metabolism
Neuralized
Neurogenic gene
Neurons - enzymology
Notch
Proneural gene
Rats
Transcription, Genetic
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
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Summary:Delta–Notch signaling is a universal cell–cell communication pathway crucial for numerous developmental and physiological processes. Several proteins interact with and regulate the Notch pathway, including the E3 ubiquitin ligase Neuralized (Neur) that influences the stability and activity of Notch ligands. In mammals there are two homologs of Neur, Neur1 and Neur2, that both can interact with Notch ligands Delta-like1 and Jagged1. Here, we show that Neur2, in contrast to Neur1, is highly expressed during embryonic development of the brain and several non-neural tissues and its mRNA levels subside postnatally. In the hippocampal neurons of the adult brain Neur2 transcripts, in contrast to Neur1, are excluded from the dendrites. Neur2 protein has a predominantly cytoplasmic localization. We also show that in addition to Delta-like1, Neur1 and Neur2 interact with another Notch ligand, Delta-like4.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2009.08.147