Intramolecular Cyclopropanation of Unsaturated Terminal Aziridines

Regio- and stereoselective deprotonation of bishomoallylic terminal N-Bus (Bus = tert-butylsulfonyl)-protected aziridines generate aziridinyl anions that undergo diastereoselective intramolecular cyclopropanation giving trans-2-aminobicyclo[3.1.0]hexanes in good to excellent yields.

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Bibliographic Details
Published in:Organic letters 2006-03, Vol.8 (5), p.995-998
Main Authors: Hodgson, David M, Humphreys, Philip G, Ward, John G
Format: Article
Language:English
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Summary:Regio- and stereoselective deprotonation of bishomoallylic terminal N-Bus (Bus = tert-butylsulfonyl)-protected aziridines generate aziridinyl anions that undergo diastereoselective intramolecular cyclopropanation giving trans-2-aminobicyclo[3.1.0]hexanes in good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol060101n